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Une approche épistémologique du microenvironnement tumoral

Sarah Yvonnet 1, 2 
1 SND - Sciences, Normes, Démocratie [Paris]
SU - Sorbonne Université, CNRS - Centre National de la Recherche Scientifique : UMR8011
Abstract : Cancer research has long been dominated by a genetic and molecular research approach of the disease. However, the accumulation of experimental data since 2000 also highlights the importance of another factor in carcinogenesis: the tumor microenvironment (TME). The study of the TME is accompanied by different assertions in the scientific literature: it would be an opportunity to improve therapies and enrich current knowledge or, on the contrary, it would be a new "paradigm" and would allow the development of new types of therapies.Our thesis proposes an analysis of the evolution of the field of oncology (and of the hypothesis of a potential scientific change) starting from the introduction of the study of the TME. We propose an original approach to this question by adopting two epistemological assumptions. First, we analyze both the scientific and medical communities. We study the continuum between fundamental research and clinical practice, articulating philosophy of biology and philosophy of medicine. Secondly, we conduct our philosophical analysis not only from a theoretical point of view but also as close as possible to the practices, behaviors, methods, and research organizations that participate in this scientific change. To do so, we will use methods rarely used in philosophy, such as semi-directive interviews or field observations.This approach aims to produce a philosophical analysis that contributes to both the philosophical and biomedical literature.
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Submitted on : Thursday, September 22, 2022 - 11:25:05 AM
Last modification on : Tuesday, October 18, 2022 - 4:31:19 AM

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YVONNET_Sarah_2021_These.pdf
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  • HAL Id : tel-03783514, version 1

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Sarah Yvonnet. Une approche épistémologique du microenvironnement tumoral. Philosophie. Sorbonne Université, 2021. Français. ⟨NNT : 2021SORUL163⟩. ⟨tel-03783514⟩

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