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STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

Abstract : Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the β-cell mass mainly through proliferation of pre-existing and newly formed β-cells. The molecular mechanism governing this process is still largely unknown. Given the inflammatory nature of PDL and inflammation-induced signaling via the signal transducer and activator of transcription 3 (STAT3), the activation and the role of STAT3 in PDL-induced β-cell proliferation were investigated. Duct ligation stimulates the expression of several cytokines that can act as ligands inducing STAT3 signaling and phosphorylation in β-cells. β-Cell cycling increased by conditional β-cell-specific Stat3 knockout and decreased by STAT3 activation through administration of interleukin-6. In addition, the level of DNA damage in β-cells of PDL pancreas increased after deletion of Stat3. These data indicate a role for STAT3 in maintaining a steady state in the β-cell, by modulating its cell cycle and protection from DNA damage.
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Contributor : Gérard Gradwohl Connect in order to contact the contributor
Submitted on : Monday, November 29, 2021 - 6:29:28 PM
Last modification on : Wednesday, December 1, 2021 - 3:47:49 AM


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S de Groef, D Renmans, Y Cai, G Leuckx, S Roels, et al.. STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage. Cell Death and Disease, Nature Publishing Group, 2016, 7 (6), pp.e2272-e2272. ⟨10.1038/cddis.2016.171⟩. ⟨inserm-03455713⟩



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