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Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

Abstract : Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-a, IFN-b…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring.
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https://www.hal.inserm.fr/inserm-03349933
Contributor : Elizabeth Bernardo Connect in order to contact the contributor
Submitted on : Tuesday, September 21, 2021 - 7:43:21 AM
Last modification on : Wednesday, October 20, 2021 - 3:19:34 AM

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Marion Grard, Camille Chatelain, Tiphaine Delaunay, Elvire Pons-Tostivint, Jaafar Bennouna, et al.. Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy. Frontiers in Oncology, Frontiers, 2021, 11, pp.695770. ⟨10.3389/fonc.2021.695770⟩. ⟨inserm-03349933⟩

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