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Iron(III) Pincer Complexes as a Strategy for Anticancer Studies

Abstract : [Fe(NCN)2]PF6 (1·PF6) [NCHN = 1,3-di(pyridin-2-yl)benzene] was readily obtained by a transmetalation reaction between [Fe3(CO)12] and Hg(NCN)Cl followed by a metathesis reaction with KPF6. X-ray diffraction, electron paramagnetic resonance spectroscopy, and cyclic voltammetry studies confirmed the proposed structure. Cytotoxic assays in human colon cancer (HCT-15), lung cancer (SKLU), and gastric cancer (AGS, KATOIII) cells were performed, and the IC50 data obtained for all cell lines showed that 1·PF6 has a much higher activity than cisplatin.
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Aldo Estrada-Montaño, Alexander Ryabov, Alexandre Gries, Christian Gaiddon, Ronan Le Lagadec. Iron(III) Pincer Complexes as a Strategy for Anticancer Studies. European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2017, 2017 (12), pp.1673-1678. ⟨10.1002/ejic.201601350⟩. ⟨inserm-02365290⟩



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