Iron(III) Pincer Complexes as a Strategy for Anticancer Studies

Abstract : [Fe(NCN)2]PF6 (1·PF6) [NCHN = 1,3-di(pyridin-2-yl)benzene] was readily obtained by a transmetalation reaction between [Fe3(CO)12] and Hg(NCN)Cl followed by a metathesis reaction with KPF6. X-ray diffraction, electron paramagnetic resonance spectroscopy, and cyclic voltammetry studies confirmed the proposed structure. Cytotoxic assays in human colon cancer (HCT-15), lung cancer (SKLU), and gastric cancer (AGS, KATOIII) cells were performed, and the IC50 data obtained for all cell lines showed that 1·PF6 has a much higher activity than cisplatin.
Complete list of metadatas

Cited literature [38 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02365290
Contributor : Christian Gaiddon <>
Submitted on : Friday, November 15, 2019 - 1:08:08 PM
Last modification on : Saturday, November 16, 2019 - 1:30:40 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Aldo Estrada-Montaño, Alexander Ryabov, Alexandre Gries, Christian Gaiddon, Ronan Le Lagadec. Iron(III) Pincer Complexes as a Strategy for Anticancer Studies. European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2017, 2017 (12), pp.1673-1678. ⟨10.1002/ejic.201601350⟩. ⟨inserm-02365290⟩

Share

Metrics

Record views

47