Use of a case-mix approach to study the trends in the incidence of second primary cancers

Boris Gass 1 Emilie Marrer 2 Simona Bara 3 Karine Ligier 3 Florence Molinié 4 Marc Colonna 5 Laetitia Daubisse-Marliac 6 Brigitte Tretarre 7 Bénédicte Lapôtre-Ledoux 8 Anne-Sophie Woronoff 9 Anne-Valérie Guizard 10 Véronique Bouvier 11 Xavier Troussard 12 Christian Gaiddon 13 Delphine Klein 14 Michel Velten 14, 15 Jérémie Jegu 16, 15
1 Registre des cancers du Bas-Rhin
2 Registre des Cancers du Haut-Rhin
3 FRANCIM
4 Registre des cancers de Loire‐Atlantique et Vendée
5 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
6 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
7 AIDMP - Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415
8 Registre du Cancer de la Somme
9 CEF2P / CARCINO - Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181)
10 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers
11 Cancers et Populations : Facteurs de Risque, Depistage, Pratiques Diagnostiques et Therapeutiques
12 CHU Caen
13 IRFAC - Inserm U1113 - Interface de Recherche Fondamentale et Appliquée en Cancérologie
14 Bas-Rhin Cancer Registry, EA 3430, Department of Epidemiology and Public Health, Faculty of Medicine
15 STREINTH - Inserm U1113 - Equipe 2 "Réponse au Stress Cellulaire & Thérapies Innovantes" / "Stress Response & Innovative Therapies"
IRFAC - Inserm U1113 - Interface de Recherche Fondamentale et Appliquée en Cancérologie
16 Registre des cancers du Tarn
Abstract : PURPOSE: To analyze trends in second primary cancer (SPC) incidence by using a case-mix approach to standardize on first cancer site distribution. METHODS: Cases registered by 13 French cancer registries between 1989 and 2010 and followed-up until June 2013 were included. The person-year approach was used to compute standardized incidence ratios (SIRs) of metachronous SPC. Usual SIRs and cancer site-specific weighted SIRs called "case-mix SIRs" (cmSIRs) were estimated by sex and calendar period of first cancer diagnosis. Calendar trends in SIRs and cmSIRs were compared. RESULTS: More than 2.9 million person-years at risk were included. Among males, SIRs dropped from 1.49 to 1.23 between 1989-1994 and 2005-2010, while cmSIRs decreased from 1.40 to 1.27. This difference seems mainly related to a stronger representation of prostate cancers (at lower risk of SPC) and a weaker contribution of bladder and head and neck cancers (at higher risk of SPC) in recent periods of diagnosis. Among females, both SIRs and cmSIRs have remained stable at around 1.22 and 1.21, respectively. CONCLUSIONS: The cmSIR is an indicator that is not influenced by changes in first cancer site distribution. Its use should be encouraged to assess second cancer incidence control.
Keywords : Confounding factors Neoplasms Reference standards Registries Risk assessment Second primary
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UNIV-TLSE3 | UNIV-FCOMTE | BACLESSE | CNRS | FNCLCC | BIOENVIS | UNIV-LYON1 | MIPS | INRIA | UNIV-MONTPELLIER | SITE-ALSACE | UNICAEN | COMUE-NORMANDIE | U1086 | UDL

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Boris Gass, Emilie Marrer, Simona Bara, Karine Ligier, Florence Molinié, et al.. Use of a case-mix approach to study the trends in the incidence of second primary cancers. Annals of Epidemiology, Elsevier Masson, 2018, 28 (5), pp.322-327. ⟨10.1016/j.annepidem.2018.02.008⟩. ⟨inserm-02364158⟩

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