Regulatory B cell generation from human Induced Pluripotent Stem Cells with a repressible granzyme B expression

Abstract : Kidney transplanted patients with long term graft survival harbor a higher frequency of B lymphocytes with regulatory properties. These “regulatory” B lymphocytes prevent effector T cell proliferation through the Granzyme B (GzmB) molecule. Our aim was to generate regulatory B lymphocytes from human Induced Pluripotent Stem (hIPS) cells with a repressible GzmB expression as a tool to better understand their function and ultimately to translate them toward clinical use.
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Poster communications
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https://www.hal.inserm.fr/inserm-02159888
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Wednesday, June 19, 2019 - 10:04:48 AM
Last modification on : Friday, November 15, 2019 - 8:44:07 AM

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  • HAL Id : inserm-02159888, version 1

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Florian Dubois, Anne Gaignerie, Léa Flippe, Jean-Marie Heslan, Laurent Tesson, et al.. Regulatory B cell generation from human Induced Pluripotent Stem Cells with a repressible granzyme B expression. FOCIS 2019, Jun 2019, Boston, United States. ⟨inserm-02159888⟩

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