Regulatory B cell generation from human Induced Pluripotent Stem Cells with a repressible granzyme B expression
Résumé
Kidney transplanted patients with long term graft survival harbor a higher frequency of B lymphocytes with regulatory properties. These “regulatory” B lymphocytes prevent effector T cell proliferation through the Granzyme B (GzmB) molecule. Our aim was to generate regulatory B lymphocytes from human Induced Pluripotent Stem (hIPS) cells with a repressible GzmB expression as a tool to better understand their function and ultimately to translate them toward clinical use.