Unbiased longitudinal brain atlas creation using robust linear registration and log-Euclidean framework for diffeomorphisms

Antoine Legouhy; Olivier Commowick; François Rousseau; Christian Barillot

Unbiased longitudinal brain atlas creation using robust linear registration and log-Euclidean framework for diffeomorphisms

Antoine Legouhy ¹ Olivier Commowick ¹ François Rousseau ² Christian Barillot ¹

1 Empenn

INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA_D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE

2 LaTIM - Laboratoire de Traitement de l'Information Medicale

Abstract : We present a new method to create a diffeomorphic longitudinal (4D) atlas composed of a set of 3D atlases each representing an average model at a given age. This is achieved by generalizing atlasing methods to produce atlases unbiased with respect to the initial reference up to a rigid transformation and ensuring diffeomorphic deformations thanks to the Baker-Campbell-Hausdorff formula and the log-Euclidean framework for diffeomorphisms. Subjects are additionally weighted using an asymmetric function to closely match specified target ages. Creating a longitudinal atlas also implies dealing with subjects with large brain differences that can lead to registration errors. This is overcome by a robust rigid registration based on polar decomposition. We illustrate these techniques for the creation of a 4D pediatric atlas, showing their ability to create a temporally consistent atlas.

Keywords : Diffeomorphism Registration Brain development Longitudinal atlas Index Terms-Longitudinal atlas

Document type :

Conference papers

Domain :

Life Sciences [q-bio] / Development Biology

Life Sciences [q-bio] / Human health and pathology

Life Sciences [q-bio] / Human health and pathology / Pediatrics

Life Sciences [q-bio] / Human health and pathology / Psychiatrics and mental health

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https://www.hal.inserm.fr/inserm-02099958
Contributor : Antoine Legouhy <>
Submitted on : Thursday, June 6, 2019 - 3:39:33 PM
Last modification on : Thursday, June 13, 2019 - 2:06:46 PM

Unbiased longitudinal brain atlas creation using robust linear registration and log-Euclidean framework for diffeomorphisms

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Unbiased longitudinal brain atlas creation using robust linear registration and log-Euclidean framework for diffeomorphisms

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