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Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.

Abstract : The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.
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https://www.hal.inserm.fr/inserm-00806868
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Submitted on : Monday, August 12, 2013 - 7:00:03 AM
Last modification on : Friday, September 18, 2020 - 2:34:46 PM
Long-term archiving on: : Wednesday, November 13, 2013 - 2:40:09 AM

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Gaël Chételat. Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.. Nature Reviews Neurology, Nature Publishing Group, 2013, 9 (3), pp.123-4. ⟨10.1038/nrneurol.2013.21⟩. ⟨inserm-00806868⟩

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