Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.
Abstract
The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
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