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Water-soluble pegylated quantum dots: from a composite hexagonal phase to isolated micelles.

Abstract : We present a simple method based on the dispersion of fluorescent quantum dots (QD) into a liquid crystal phase that provides either nanostructured material or isolated QD micelles depending on water concentration. The liquid-crystal phase was obtained by using a gallate amphiphile with a poly(ethylene glycol) chain as the polar headgroup, named I. The hydration of QD/I mixtures resulted in the formation of a composite hexagonal phase identified by small-angle X-ray scattering and by polarized light and fluorescence optical microscopy, showing a homogeneous distribution of fluorescence within hexagonal phase. This composite mesophase can be converted into isolated QD-I micelles by dilution in water. The fluorescent QD-I micelles, purified by size exclusion chromatography, are well monodisperse with a hydrodynamic diameter of 20-30 nm. Moreover, these QD do not show any nonspecific adsorption on lipid or cell membranes. By simply adjusting the water content, the PEG gallate amphiphile I provides a simple method to prepare a self-organized composite phase or pegylated water soluble QD micelles for biological applications.
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Contributor : Isabelle Arnal <>
Submitted on : Wednesday, July 6, 2011 - 10:13:20 AM
Last modification on : Thursday, July 1, 2021 - 5:32:04 PM

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Fouzia Boulmedais, Patrick Bauchat, Marie-Josèphe Brienne, Isabelle Arnal, Franck Artzner, et al.. Water-soluble pegylated quantum dots: from a composite hexagonal phase to isolated micelles.. Langmuir, American Chemical Society, 2006, 22 (23), pp.9797-803. ⟨10.1021/la061849h⟩. ⟨inserm-00606333⟩



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