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The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering.

Abstract : In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.
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https://www.hal.inserm.fr/inserm-00352650
Contributor : Samia Laïb <>
Submitted on : Tuesday, January 13, 2009 - 2:35:01 PM
Last modification on : Friday, November 6, 2020 - 4:02:21 AM

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Samia Laïb, Borhane Fellah, Ahmed Fatimi, Sophie Quillard, Claire Vinatier, et al.. The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering.. Biomaterials, Elsevier, 2008, epub ahead of print. ⟨10.1016/j.biomaterials.2008.11.031⟩. ⟨inserm-00352650⟩

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