The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Biomaterials Année : 2008

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering.

Sylvain Bohic

Résumé

In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.

Domaines

Biomatériaux

Dates et versions

inserm-00352650 , version 1 (13-01-2009)

Identifiants

Citer

Samia Laïb, Borhane H. Fellah, Ahmed Fatimi, Sophie Quillard, Claire Vinatier, et al.. The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering.. Biomaterials, 2008, epub ahead of print. ⟨10.1016/j.biomaterials.2008.11.031⟩. ⟨inserm-00352650⟩
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