A simple reaction to produce small structurally complex and diverse molecules
Résumé
In order to mimic the complexity of natural products, we designed and obtained with simple synthetic methods, building blocks with 'quaternary chiral centers'. These tricyclic lactams resulted from the reaction of a functional [gamma]-keto-acid and various commercially available bi-nucleophiles.
We describe the stereoselective synthesis of tricyclic lactams containing a chiral quaternary center and suitable for the synthesis of chemical libraries in order to mimic the complexity of natural compounds.
Domaines
Sciences pharmaceutiques
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