Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

Stéphane Bretagne; Karine Sitbon; Marie Desnos-Ollivier; Dea Garcia-Hermoso; Valérie Letscher-Bru; Sophie Cassaing; Laurence Millon; Florent Morio; Jean-Pierre Gangneux; Lilia Hasseine; Loïc Favennec; Estelle Cateau; Eric Bailly; Maxime Moniot; Julie Bonhomme; Nicole Desbois-Nogard; Taieb Chouaki; André Paugam; Bernard Bouteille; Marc Pihet; Frédéric Dalle; Odile Eloy; Milène Sasso; Magalie Demar; Patricia Mariani-Kurkdjian; Vincent Robert; Olivier Lortholary; Françoise Dromer; The French Mycoses Study Group; Céline Damiani; Hervé Dupont; Julien Maizel; Anne Totet; Jean-Philippe Bouchara; Anne Pauline Bellanger; Ana Berceanu; Jean Christophe Navellou; Emeline Scherer; Philippe Abboud; Christine Aznar; Denis Blanchet; Félix Djossou; Sophie Cayot; Cyril Garrouste; Olivier Lesens; Cécile Moluçon; Céline Nourrisson; Philippe Poirier; Éloïse Bailly; Louise Basmaciyan; Bouhemad Belaid; Mathieu Blot; Denis Caillot; Pierre-Emmanuel Charles; Jean Pierre Quenot; Emmanuelle Amazan; Emilie Baubion; André Cabie; Cyrille Chabartier; Christophe Deligny; Violaine Emal; Olivier Flechelle; Yves Hatchuel; Yohann Le Govic; Harold Merle; Charline Miossec; Jean-Marie Turmel; Ruddy Valentino; Marie-Fleur Durieux; Pascal Turlure; Victor Mercier; Martine Gari-Toussaint; Karine Risso; Loïc Simon; Cedric Bretonnière; David Boutoille; Thomas Gastinne; Karim Lakhal; Elise Launay; Thierry Lepoivre; Pierre Peterlin; Fanny Rialland; Patrice Le Pape; Etienne Canoui; Naima Dahane; Solène Kerneis; Cécile Angebault; Marie-Elisabethh Bougnoux; Nadia Guennouni; Fanny Lanternier; Bennedicte Neven; Mehdi Oualha; Anne Scemla; Emilie Sitterlé; Felipe Suarez; Julie Toubiana; Stéphane Bonacorci; Alexandre Alanio; Anne Bergeron; Blandine Denis; Maud Gits-Muselli; Samia Hamane; Sophie Touratier; Christine Chaumeil; Lilia Merabet; Joelle Claudéon; Elodie Curlier; Valérie Galantine; Jean Claude Gallois; Samuel Markowicz; Muriel Nicolas; Pascal Musson; Kinda Schepers; Alida Minoza; Catherine Kauffmann-Lacroix; Hélène Guégan; Damien Costa; Marion Dehais; Gilles Gargala; Odile Bajolet; Firouze Banisadr; Joel Cousson; Chantal Himberlin; Antoine Huguenin; Dominique Toubas; Pierre Flori; Caroline Mahinc; Hélène Raberin; Julie Denis; Raoul Herbrecht; Paul-Michel Mertes; Fehrat Meziani; Marcela Sabou; Francis Schneider; Anne-Isabelle Bertozzi; Pamela Chauvin; Elena Charpentier; Olivier Cointault; Claire Cottrel; Karen Delavigne; Stanislas Faguer; Judith Fillaux; Emilie Guemas; Xavier Iriart; Lucie Lelièvre; Jean Ruiz; Frédéric Bastides; Adélaïde Chesnay; Guillaume Desoubeaux; Audrey Therby; Elisabeth Chachaty; Bertrand Gachot

doi:10.1128/mbio.00920-22

Journal Articles mBio Year : 2022

Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

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Stéphane Bretagne

Function : Author
PersonId : 756896
ORCID : 0000-0001-6870-3800
IdRef : 076112586

Mycologie moléculaire - Molecular Mycology

Hopital Saint-Louis [AP-HP]

Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

Karine Sitbon

Function : Author

Mycologie moléculaire - Molecular Mycology

Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

Marie Desnos-Ollivier

Function : Author
PersonId : 746841
IdHAL : desnos-ollivier-marie
ORCID : 0000-0002-9137-0466

Mycologie moléculaire - Molecular Mycology

Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

Dea Garcia-Hermoso

Function : Author
PersonId : 1273549
IdHAL : dea-garcia-hermoso
ORCID : 0000-0001-5288-2904

Mycologie moléculaire - Molecular Mycology

Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

Valérie Letscher-Bru

Function : Author
PersonId : 1049989
IdHAL : florent-morio
ORCID : 0000-0002-5859-6105
IdRef : 117992259

Dynamique des interactions hôte pathogène

Sophie Cassaing

Function : Author
PersonId : 762219
ORCID : 0000-0003-0055-0136
IdRef : 063245000

Centre Hospitalier Universitaire de Toulouse

Geroscience and rejuvenation research center

Laurence Millon

Function : Author
PersonId : 760476
ORCID : 0000-0001-5939-3409
IdRef : 058504656

Laboratoire Chrono-environnement (UMR 6249)

Florent Morio

Function : Author
PersonId : 1049989
IdHAL : florent-morio
ORCID : 0000-0002-5859-6105
IdRef : 117992259

Nantes Université

Jean-Pierre Gangneux

Function : Author
PersonId : 756001
ORCID : 0000-0002-4974-5607
IdRef : 074162063

Institut de recherche en santé, environnement et travail

Lilia Hasseine

Function : Author

Centre Hospitalier Universitaire de Nice

Loïc Favennec

Function : Author

CHU Rouen

Estelle Cateau

Function : Author

Centre hospitalier universitaire de Poitiers = Poitiers University Hospital

Écologie et biologie des interactions

Eric Bailly

Function : Author

Centre Hospitalier Régional Universitaire de Tours

Maxime Moniot

Function : Author

CHU Clermont-Ferrand

Julie Bonhomme

Function : Author

CHU Caen

Nicole Desbois-Nogard

Function : Author

CHU de la Martinique [Fort de France]

Taieb Chouaki

Function : Author

CHU Amiens-Picardie

André Paugam

Function : Author

Hôpital Cochin [AP-HP]

Bernard Bouteille

Function : Author

CHU Limoges

Marc Pihet

Function : Author

SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques

Laboratoire de Parasitologie-Mycologie (CHU d'Angers)

Infections Respiratoires Fongiques

Frédéric Dalle

Function : Author

Procédés Alimentaires et Microbiologiques [Dijon]

Odile Eloy

Function : Author

Centre Hospitalier de Versailles André Mignot

Milène Sasso

Function : Author
PersonId : 741106
IdHAL : milene-sasso
ORCID : 0000-0002-6539-8545
IdRef : 18410002X

Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle

Magalie Demar

Function : Author
PersonId : 812217
ORCID : 0000-0003-3414-0821
IdRef : 144458918

Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]

Patricia Mariani-Kurkdjian

Function : Author

Hôpital Robert Debré Paris

Vincent Robert

Function : Author

Westerdijk Fungal Biodiversity Institute [Utrecht]

Olivier Lortholary

Function : Author

Mycologie moléculaire - Molecular Mycology

Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

Service des Maladies infectieuses et tropicales [CHU Necker]

Françoise Dromer

Function : Correspondent author
PersonId : 182926
IdHAL : francoise-dromer
ORCID : 0000-0003-1671-1475
IdRef : 074496492

Connectez-vous pour contacter l'auteur

Mycologie moléculaire - Molecular Mycology

Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

The French Mycoses Study Group

Function : Author
PersonId : 1035501

Céline Damiani

Function : Author
PersonId : 1145690
ORCID : 0000-0003-3532-6775
IdRef : 139902953

Agents infectieux, résistance et chimiothérapie - UR UPJV 4294

Hervé Dupont

Function : Author
PersonId : 913042
ORCID : 0000-0002-5644-3412
IdRef : 089058127

Simplification des soins chez les patients complexes - UR UPJV 7518

Julien Maizel

Function : Author
PersonId : 926124
ORCID : 0000-0001-5975-2635
IdRef : 111324203

Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517

Anne Totet

Function : Author
PersonId : 890610
IdHAL : totetanne
IdRef : 079379257

Agents infectieux, résistance et chimiothérapie - UR UPJV 4294

Jean-Philippe Bouchara

Function : Author

Infections Respiratoires Fongiques

SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques

Laboratoire de Parasitologie-Mycologie [CHU Angers]

Anne Pauline Bellanger

Function : Author

Ana Berceanu

Function : Author

Jean Christophe Navellou

Function : Author

Emeline Scherer

Function : Author

Philippe Abboud

Function : Author

Christine Aznar

Function : Author

Denis Blanchet

Function : Author
PersonId : 770220
ORCID : 0000-0003-3270-2093

Félix Djossou

Function : Author
PersonId : 812856
ORCID : 0000-0002-6761-0511

Sophie Cayot

Function : Author

Cyril Garrouste

Function : Author
PersonId : 761576
ORCID : 0000-0001-5166-5617

Olivier Lesens

Function : Author

Cécile Moluçon

Function : Author

Céline Nourrisson

Function : Author
PersonId : 1220119
IdHAL : celine-nourrisson
ORCID : 0000-0002-4003-805X

Philippe Poirier

Function : Author
PersonId : 763271
ORCID : 0000-0001-9173-2634
IdRef : 129374989

Éloïse Bailly

Function : Author

Louise Basmaciyan

Function : Author
PersonId : 780997
ORCID : 0000-0003-4214-8022

Bouhemad Belaid

Function : Author

Mathieu Blot

Function : Author

Denis Caillot

Function : Author

Pierre-Emmanuel Charles

Function : Author

Jean Pierre Quenot

Function : Author
PersonId : 998462
ORCID : 0000-0003-2351-682X
IdRef : 079287654

Emmanuelle Amazan

Function : Author

Emilie Baubion

Function : Author

André Cabie

Function : Author

Cyrille Chabartier

Function : Author

Christophe Deligny

Function : Author

Violaine Emal

Function : Author

Olivier Flechelle

Function : Author

Yves Hatchuel

Function : Author

Yohann Le Govic

Function : Author
PersonId : 1098063
ORCID : 0000-0001-7686-4612
IdRef : 257468021

Agents infectieux, résistance et chimiothérapie - UR UPJV 4294

Harold Merle

Function : Author

Charline Miossec

Function : Author

Jean-Marie Turmel

Function : Author

Ruddy Valentino

Function : Author

Marie-Fleur Durieux

Function : Author

Pascal Turlure

Function : Author

Victor Mercier

Function : Author

Martine Gari-Toussaint

Function : Author

Karine Risso

Function : Author

Loïc Simon

Function : Author

Cedric Bretonnière

Function : Author

David Boutoille

Function : Author
PersonId : 9826
IdHAL : aalanio
ORCID : 0000-0001-9726-3082
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Thomas Gastinne

Function : Author

Karim Lakhal

Function : Author

Elise Launay

Function : Author
PersonId : 781470
ORCID : 0000-0002-4081-4653
IdRef : 112852688

Thierry Lepoivre

Function : Author

Pierre Peterlin

Function : Author
PersonId : 776625
ORCID : 0000-0001-5463-6686

Fanny Rialland

Function : Author

Patrice Le Pape

Function : Author

Etienne Canoui

Function : Author

Naima Dahane

Function : Author

Solène Kerneis

Function : Author

Cécile Angebault

Function : Author
PersonId : 1197471
ORCID : 0000-0001-7641-3002

Marie-Elisabethh Bougnoux

Function : Author

Nadia Guennouni

Function : Author

Fanny Lanternier

Function : Author

Bennedicte Neven

Function : Author

Mehdi Oualha

Function : Author

Anne Scemla

Function : Author

Emilie Sitterlé

Function : Author

Felipe Suarez

Function : Author
PersonId : 758757
ORCID : 0000-0002-3537-9052

Julie Toubiana

Function : Author
PersonId : 799686
ORCID : 0000-0001-9561-669X
IdRef : 150776640

Stéphane Bonacorci

Function : Author

Alexandre Alanio

Function : Author

Anne Bergeron

Function : Author

Blandine Denis

Function : Author

Maud Gits-Muselli

Function : Author

Samia Hamane

Function : Author

Sophie Touratier

Function : Author

Christine Chaumeil

Function : Author

Lilia Merabet

Function : Author

Joelle Claudéon

Function : Author

Elodie Curlier

Function : Author

Valérie Galantine

Function : Author

Jean Claude Gallois

Function : Author

Samuel Markowicz

Function : Author

Muriel Nicolas

Function : Author

Pascal Musson

Function : Author

Kinda Schepers

Function : Author

Alida Minoza

Function : Author

Catherine Kauffmann-Lacroix

Function : Author

Hélène Guégan

Function : Author

Damien Costa

Function : Author
PersonId : 1156207
IdHAL : damien-costa
ORCID : 0000-0003-3418-2597
IdRef : 187114048

Marion Dehais

Function : Author

Gilles Gargala

Function : Author

Odile Bajolet

Function : Author

Firouze Banisadr

Function : Author

Joel Cousson

Function : Author

Chantal Himberlin

Function : Author

Antoine Huguenin

Function : Author

Dominique Toubas

Function : Author

Pierre Flori

Function : Author

Caroline Mahinc

Function : Author

Hélène Raberin

Function : Author

Julie Denis

Function : Author

Raoul Herbrecht

Function : Author
PersonId : 759015
ORCID : 0000-0002-9381-4876
IdRef : 055827160

Paul-Michel Mertes

Function : Author
PersonId : 807672
ORCID : 0000-0002-6060-9438

Fehrat Meziani

Function : Author

Marcela Sabou

Function : Author

Francis Schneider

Function : Author
PersonId : 1116934
ORCID : 0000-0002-7481-5101

Anne-Isabelle Bertozzi

Function : Author

Pamela Chauvin

Function : Author

Elena Charpentier

Function : Author
PersonId : 1165717

Olivier Cointault

Function : Author

Claire Cottrel

Function : Author

Karen Delavigne

Function : Author

Stanislas Faguer

Function : Author
PersonId : 944616
ORCID : 0000-0003-0553-0927
IdRef : 146284135

Judith Fillaux

Function : Author

Emilie Guemas

Function : Author

Xavier Iriart

Function : Author
PersonId : 994510
ORCID : 0000-0002-0998-8962

Lucie Lelièvre

Function : Author

Jean Ruiz

Function : Author

Frédéric Bastides

Function : Author

Adélaïde Chesnay

Function : Author
PersonId : 799486
ORCID : 0000-0001-6218-2442

Guillaume Desoubeaux

Function : Author
PersonId : 953179
ORCID : 0000-0001-7945-9890
IdRef : 130306711

Hôpital Bretonneau

Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100

Audrey Therby

Function : Author

Elisabeth Chachaty

Function : Author

Bertrand Gachot

Function : Author

Abstract

The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools. IMPORTANCE The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs. Globally, although the incidence of Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis remained stable over the study period (2012 to 2018), that of yeast fungemia increased slightly. We also show here that IFDs seem to affect older people more frequently. The most worrisome observation is the lack of improvement in the global survival rate associated with IFDs despite the increasing use of more sensitive diagnostic tools, the availability of new antifungal drugs very active in clinical trials, and a still low/marginal rate of acquired in vitro resistance in France. Therefore, other tracks of improvement should be investigated actively.

Keywords

aspergillosis candidemia epidemiology invasive fungal infections mucormycosis pneumocytosis aspergillosis

Domains

Life Sciences [q-bio] Microbiology and Parasitology Mycology

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Submitted on : Wednesday, May 4, 2022-1:32:21 PM

Last modification on : Tuesday, April 23, 2024-11:22:11 AM

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hal-03658122 , version 1 (04-05-2022)

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HAL Id : hal-03658122 , version 1
DOI : 10.1128/mbio.00920-22
PUBMED : 35499498
PUBMEDCENTRAL : PMC9239099

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Stéphane Bretagne, Karine Sitbon, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Valérie Letscher-Bru, et al.. Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018). mBio, 2022, 13 (3), pp.e0092022. ⟨10.1128/mbio.00920-22⟩. ⟨hal-03658122⟩

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Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

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