Skip to Main content Skip to Navigation
Journal articles

High Mortality and Graft Loss after Infective Endocarditis in Kidney Transplant Recipients: A Case-Controlled Study from Two Centers

Abstract : Kidney transplant recipients (KTRs) tend to develop infections with characteristic epidemiology, presentation, and outcome. While infective endocarditis (IE) is among such complications in KTRs, the literature is scarce. We describe the presentation, epidemiology, and factors associated with IE in KTRs. We performed a retrospective case/control study which included patients from two centers. First episodes of definite or possible IE (Duke criteria) in adult KTRs from January 2010 to December 2018 were included, as well as two controls per case, and followed until 31 December 2019. Clinical, biological, and microbiological data and the outcome were collected. Survival was studied using the Kaplan–Meier method. Finally, we searched for factors associated with the onset of IE in KTRs by the comparison of cases and controls. Seventeen cases and 34 controls were included. IE was diagnosed after a mean delay of 78 months after KT, mostly on native valves of the left heart only. Pathogens of digestive origin were most frequently involved (six Enterococcus spp, three Streptococcus gallolyticus, and one Escherichia coli), followed by Staphylococci (three cases of S. aureus and S. epidermidis each). Among the risk factors evaluated, age, vascular nephropathy, and elevated calcineurin inhibitor through levels were significantly associated with the occurrence of IE in our study. Patient and death-censored graft survival were greatly diminished five years after IE, compared to controls being 50.3% vs. 80.6% (p < 0.003) and 29.7% vs. 87.5% (p < 0.002), respectively. IE in KTRs is a disease that carries significant risks both for the survival of the patient and the transplant.
Document type :
Journal articles
Complete list of metadata

https://hal.sorbonne-universite.fr/hal-03353720
Contributor : Hal Sorbonne Université Gestionnaire Connect in order to contact the contributor
Submitted on : Friday, September 24, 2021 - 11:56:32 AM
Last modification on : Wednesday, October 20, 2021 - 1:31:26 AM

File

pathogens-10-01023.pdf
Publication funded by an institution

Identifiers

`

Citation

Yanis Tamzali, Clément Danthu, Alexandra Aubry, Romain Brousse, Jean-François Faucher, et al.. High Mortality and Graft Loss after Infective Endocarditis in Kidney Transplant Recipients: A Case-Controlled Study from Two Centers. Pathogens, MDPI, 2021, 10 (8), pp.1023. ⟨10.3390/pathogens10081023⟩. ⟨hal-03353720⟩

Share

Metrics

Record views

30

Files downloads

18