Skip to Main content Skip to Navigation
Journal articles

Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges

Abstract : Having first been developed for ultrasound imaging, nowadays, microbubbles are proposed as tools for ultrasound-assisted gene delivery, too. Their behavior during ultrasound exposure causes transient membrane permeability of surrounding cells, facilitating targeted local delivery. The increased cell uptake of extracellular compounds by ultrasound in the presence of microbubbles is attributed to a phenomenon called sonoporation. Sonoporation has been successfully applied to deliver nucleic acids in vitro and in vivo in a variety of therapeutic applications. However, the biological and physical mechanisms of sonoporation are still not fully understood. In this review, we discuss recent data concerning microbubble–cell interactions leading to sonoporation and we report on the progress in ultrasound-assisted therapeutic gene delivery in different organs. In addition, we outline ongoing challenges of this novel delivery method for its clinical use.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03193228
Contributor : Michiel Postema <>
Submitted on : Thursday, April 15, 2021 - 5:22:13 PM
Last modification on : Thursday, April 22, 2021 - 8:50:02 PM

Files

TD06062012.pdf
Files produced by the author(s)

Identifiers

Citation

Anthony Delalande, Michiel Postema, Nathalie Mignet, Patrick Midoux, Chantal Pichon. Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges. Therapeutic Delivery, Future Science Ltd, 2012, 3 (10), pp.1199-1215. ⟨10.4155/TDE.12.100⟩. ⟨hal-03193228⟩

Share

Metrics

Record views

34

Files downloads

21