Serum CXCL10, CXCL11, CXCL12, and CXCL14 chemokine patterns in patients with acute liver injury

The chemokines CXCL10 (interferon ϒ-inducible protein 10 [IP-10]), CXCL11 (Human interferon inducible T cell alpha chemokine [I-TAC]), CXCL12 (stromal cell derived factor 1 [SDF-1]), and CXCL14 (breast and kidney-expressed chemokine [BRAK]) are involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. However, their expression in patients with acute liver injury is unknown. Here, we aimed to provide evidence of the presence of circulating CXCL10, CXCL11, CXCL12, and CXCL14 during human acute liver injury to propose new inflammation biomarkers for acute liver injury.

Mots clés

CXCL14 Acute liver injury CXCL10 CXCL11 CXCL12

Domaines

Hépatologie et Gastroentérologie Génomique, Transcriptomique et Protéomique [q-bio.GN]

Fichier principal

Chalin_Serum CXCL10.pdf (311.02 Ko)

Origine : Fichiers produits par l'(les) auteur(s)

Laurent Jonchère : Connectez-vous pour contacter le contributeur

https://univ-rennes.hal.science/hal-01863796

Soumis le : lundi 3 septembre 2018-14:10:35

Dernière modification le : jeudi 18 janvier 2024-10:22:15

Archivage à long terme le : mardi 4 décembre 2018-14:54:29

Dates et versions

hal-01863796 , version 1 (03-09-2018)

hal-01863796 , version 2 (18-10-2018)

Identifiants

HAL Id : hal-01863796 , version 1
DOI : 10.1016/j.cyto.2018.05.029
PUBMED : 29880273

Citer

Arnaud Chalin, Benjamin Lefèvre, Christelle Devisme, Charlotte Pronier, Virginie Carrière, et al.. Serum CXCL10, CXCL11, CXCL12, and CXCL14 chemokine patterns in patients with acute liver injury. Cytokine, In press, ⟨10.1016/j.cyto.2018.05.029⟩. ⟨hal-01863796v1⟩

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