Toll-like receptor expression and function differ between splenic marginal zone B cell lymphoma and splenic diffuse red pulp B cell lymphoma

Abstract : In splenic marginal zone lymphoma (SMZL), specific and functional Toll-like Receptor (TLR) patterns have been recently described, suggesting their involvement in tumoral proliferation. Splenic diffuse red pulp lymphoma with villous lymphocytes (SDRPL) is close to but distinct from SMZL, justifying here the comparison of TLR patterns and functionality in both entities. Distinct TLR profiles were observed in both lymphoma subtypes. SDRPL B cells showed higher expression of TLR7 and to a lesser degree TLR9, in comparison to SMZL B cells. In both entities, TLR7 and TLR9 pathways appeared functional, as shown by IL-6 production upon TLR7 and TLR9 agonists stimulations. Interestingly, circulating SDRPL, but not SMZL B cells, constitutively expressed CD86. In addition, stimulation with both TLR7 and TLR9 agonists significantly increased CD80 expression in circulating SDRPL but not SMZL B cells. Finally, TLR7 and TLR9 stimulations had no impact on proliferation and apoptosis of SMZL or SDRPL B cells. In conclusion, SMZL and SDRPL may derive from different splenic memory B cells with specific immunological features that can be used as diagnosis markers in the peripheral blood.
Type de document :
Article dans une revue
Oncotarget, Impact journals, 2018, 9 (34), pp.23589-23598. 〈10.18632/oncotarget.25283〉
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-01859559
Contributeur : Laurence Naiglin <>
Soumis le : mercredi 10 octobre 2018 - 15:06:03
Dernière modification le : vendredi 9 novembre 2018 - 16:52:02

Fichier

oncotarget-09-23589.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Aurélie Verney, Alexandra Traverse-Glehen, Evelyne Callet-Bauchu, Laurent Jallades, Jean-Pierre Magaud, et al.. Toll-like receptor expression and function differ between splenic marginal zone B cell lymphoma and splenic diffuse red pulp B cell lymphoma. Oncotarget, Impact journals, 2018, 9 (34), pp.23589-23598. 〈10.18632/oncotarget.25283〉. 〈hal-01859559〉

Partager

Métriques

Consultations de la notice

82

Téléchargements de fichiers

4