Diaphragm dysfunction during weaning from mechanical ventilation: an underestimated phenomenon with clinical implications

Abstract : Recent findings suggest that diaphragm dysfunction is frequently involved during weaning failure and that it is associated with poor prognosis at time of liberation from mechanical ventilation. Until recently, exploration of the diaphragm has not been convenient to achieve at the bedside. This factor may explain the growing interest in ultrasound. Diaphragm ultrasound provides non-invasive indices that describe the structure and the function of the muscle. Herein, we summarize the mechanisms of diaphragm dysfunction in the critically ill and describe current approaches aimed at assessing diaphragm function at the bedside. We discuss some recent aspects of the epidemiology and risk factors for diaphragm dysfunction at the time of weaning from mechanical ventilation. Finally, latest advances regarding preventive and curative strategies for diaphragm dysfunction are presented.
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Soumis le : lundi 9 avril 2018 - 10:31:42
Dernière modification le : mardi 10 avril 2018 - 16:54:17

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Martin Dres, Alexandre Demoule. Diaphragm dysfunction during weaning from mechanical ventilation: an underestimated phenomenon with clinical implications. Critical Care, BioMed Central, 2018, 22, pp.73. 〈10.1186/s13054-018-1992-2〉. 〈hal-01761437〉

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