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Design et fonctionnalisation d’hétérocycles originaux de type bicycliques [5-5] et tricycliques [6-5-6] à visée thérapeutique potentielle

Abstract : The access to new original biologically active heterocyclic compounds, is one of the main objectives of our research group. In this context, the main purpose of this thesis is the design of three new families of heterocyclic compounds containing a pyrazolic motif that may exhibit biological activities, namely pyrido[1',2': 1.5]pyrazolo[4,3-d]pyrimidine, pyrrolo[3,4-c]pyrazole and pyrazolo[5,1-b]thiazole.This manuscript is essentially dedicated to a methodology work describing the different routes of access to these originals and potentially modular tricyclic and bicyclic precursors. The reactivity of these key synthons is then studied towards aromatic nucleophilic substitutions reactions and various pallado-catalyzed methods of functionalization (Activation with PyBrOP- (hetero) arylation, Liebeskind-Srogl, Suzuki-Miyaura, Buchwald-Hartwig, C-H arylation, aromatic nucleophilic substitution) to develop interesting libraries built around these unusual structures, thus opening numerous pharmacological perspectives.
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Submitted on : Thursday, June 30, 2022 - 10:16:32 AM
Last modification on : Friday, July 1, 2022 - 11:44:26 AM

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  • HAL Id : tel-03709731, version 1

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Abdelaziz Ejjoummany. Design et fonctionnalisation d’hétérocycles originaux de type bicycliques [5-5] et tricycliques [6-5-6] à visée thérapeutique potentielle. Chimie organique. Université d'Orléans; Université Hassan II (Casablanca, Maroc), 2020. Français. ⟨NNT : 2020ORLE3141⟩. ⟨tel-03709731⟩

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