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Arterial spin labeling performance in resting-state functional MRI: the effect of scan duration

Corentin Vallée 1
1 Empenn
INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : Resting-state Arterial Spin Labeling (rsASL) in clinical routine and academic research remains confidential compared to resting-state BOLD. However, unlike BOLD, ASL provides with direct access to cerebral blood flow (CBF). This could lead to significant clinical subject scaled application as ASL is a non-invasive measurement of CBF (disease with CBF impairment follow-up, longitudinal studies of healthy subjects, etc.). Despite the significant increasing involvement of all MRI stakeholders is ASL over the past decade, the question of the acquisition duration (AD) in rsASL seems to have never been addressed in the literature, despite its strong practical consequences and its impact on functional networks representation. In this thesis, and as a preliminary work on the subject, we will first discuss how to study the role of AD in rsASL with simple methods that model what a researcher in rsMRI might experience. Our results show that the representation of functional networks stabilizes after a certain acquisition time for common functional networks. In a second part, we study the performance of the ASL in resting-state compared to the BOLD resting-state, while keeping the AD as a parameter. We show that the rsBOLD outperforms the rsASL on most aspects, but not on all. The ability to quantify the CBF, unlike the BOLD, tends to confirm that rsASL in particular and ASL in general deserve even more involvement from the functional MRI community.
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https://www.hal.inserm.fr/tel-03139300
Contributor : Corentin Vallée <>
Submitted on : Thursday, February 11, 2021 - 8:14:50 PM
Last modification on : Sunday, February 14, 2021 - 3:09:20 AM
Long-term archiving on: : Wednesday, May 12, 2021 - 7:16:17 PM

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  • HAL Id : tel-03139300, version 1

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Corentin Vallée. Arterial spin labeling performance in resting-state functional MRI: the effect of scan duration. Neuroscience. Université de rennes 1, 2020. English. ⟨tel-03139300⟩

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