, A novel method for real-time quantitative RT-PCR, Genome Res, vol.6, pp.995-1001, 1996.
, Pathology of the human placenta, 2000.
, Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta, Histochem Cell Biol, vol.110, pp.495-508, 1998.
, Proliferation, differentiation and apoptosis in villous trophoblast at 13-41 weeks of gestation (including observations on annulate lamellae and nuclear pore complexes), Placenta, vol.20, pp.407-429, 1999.
, Villous trophoblast of human placenta: a coherent view of its turnover, repair and contributions to villous development and maturation, Histol Histopathol, vol.16, pp.1213-1237, 2001.
, Stereological evaluation of vascular adaptations in human placental villi to differing forms of hypoxic stress, Placenta, vol.17, pp.49-55, 1996.
, Villous trophoblast: morphometric perspectives on growth, differentiation, turnover and deposition of fibrin-type fibrinoid during gestation, Placenta, vol.22, pp.628-666, 2001.
, Hypobaric hypoxia and villous trophoblast: evidence that human pregnancy at high altitude (3600 m) perturbs epithelial turnover and coagulation-fibrinolysis in the intervillous space, Placenta, vol.23, pp.154-62, 2002.
, From 13 weeks to term, the trophoblast of human placenta grows by the continuous recruitment of new proliferative units: a study of nuclear number using the disector, Placenta, vol.13, pp.501-513, 1992.
, Secretion of chorionic gonadotropin from human trophoblasts, Placenta, vol.18, pp.237-278, 1997.
, The central role of human chorionic gonadotropin in the formation of human placental syncytium, Endocrinology, vol.144, pp.1108-1128, 2003.
, The physiology of placental lactogen in human pregnancy, Endocrinology, vol.12, pp.329-365, 1991.
, Evain-Brion D. Human placental growth hormone, Am J Obstet Gynecol, vol.177, pp.1526-1560, 1997.
, Evain-Brion D. Human placental growth hormone-a review, Placenta, vol.23, pp.87-94, 2002.
, Antibody reaction patterns in first trimester placenta: implications for trophoblast isolation and purity screening, Placenta, vol.21, pp.733-774, 2000.
, Cell culture models of human trophoblast-primary culture of trophoblast-a workshop report, Placenta, vol.21, pp.120-122, 2000.
, PPAR gamma/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation, Endocrinology, vol.142, pp.4504-4518, 2001.
, Expression of PPAR and RXR isoforms in the developing rat and human term placentas, Placenta, vol.23, pp.661-71, 2002.
, Evain-Brion D. The expression of nuclear retinoid receptors in human implantation, Placenta, vol.21, pp.703-713, 2000.
, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction, Anal Biochem, vol.162, pp.156-165, 1987.
, Evain-Brion D. Modulation of copper/zinc superoxide dismutase expression and activity with in vitro differentiation of human villous cytotrophoblast, Placenta, vol.21, pp.773-81, 2000.
, Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down syndrome, J Clin Endocrinol Metab, vol.85, pp.3700-3707, 2000.
URL : https://hal.archives-ouvertes.fr/inserm-00128454
, PPARgamma/RXRalpha heterodimers control human trophoblast invasion, J Clin Endocrinol Metab, vol.86, pp.5017-5041, 2001.
, Classification of human placental villi, II. Morphometry. Cell Tissue Res, vol.200, pp.425-459, 1979.
, Distribution of components of the glutathione detoxification system across the human placenta after uncomplicated vaginal deliveries, Placenta, vol.23, pp.490-496, 2002.
, Variability of Trophoblast Genes in Total Placenta, vol.5
, Mise en évidence d'une fixation spécifique de gonadotrophine chorionique humaine radio-iodée dans les tranches de placentas humains, C. R. Acad, vol.278, pp.2665-2668, 1974.
, Increase in epidermal growth factor receptor and its messenger ribonucleic acid levels with differentiation of human trophoblast cells in culture, J Cell Physiol, vol.154, pp.122-128, 1993.
, Evain-Brion D 1991. Parathyroid hormone increases epidermal growth factor receptors in cultured human trophoblastic cells from early and term placenta, J Clin Endocrinol Metab, vol.73, pp.288-294
, Hypoxia impairs cell fusion and differentiation process in human cytotrophoblast, in vitro, J Cell Physiol, vol.168, pp.346-353, 1996.
, Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidence in vivo and in vitro, J Cell Sci, vol.99, pp.681-692, 1991.
, The lutropin/choriogonadotropin receptor, a 2002 perspective, Endocr Rev, vol.23, pp.141-174, 2002.
, Pathology of the human placenta, 2000.
, Antibody reaction patterns in first trimester placenta: implications for trophoblast isolation and purity screening, Placenta, vol.21, pp.733-741, 2000.
, Identification of the transcriptionnally active genes of the chorionic gonadotrophin beta gene cluster in vivo, J Biol Chem, vol.267, pp.3179-3184, 1992.
, The human placenta. Heffer and Sons, 1970.
, Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin, Endocrinology, vol.135, pp.402-408, 1994.
, Connexin expression and gap junctional intercellular communication in human first trimester trophoblast, Mol Hum Reprod, vol.8, pp.1005-1013, 2002.
, 8-Bromo-3',5'-adenosine monophosphate stimulates the endocrine activity of human cytotrophoblasts in culture, J Clin Endocrinol Metab, vol.63, pp.1211-1217, 1986.
, Involvement of connexin 43 in human trophoblast cell fusion and differentiation, J Cell Sci, vol.116, pp.3413-3421, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128436
, Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation, Mol Cell Biol, vol.23, pp.3566-3574, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128429
, Trophoblast production of a weakly bioactive human chorionic gonadotropin in trisomy 21-affected pregnancy, J Clin Endocrinol Metab, vol.89, pp.727-732, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-00128419
, Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation, Endocrinology, vol.142, pp.3638-3648, 2001.
URL : https://hal.archives-ouvertes.fr/inserm-00128447
, Modulation of copper/zinc Superoxide Dismutase expression and activity with in vitro differentiation of human villous cytotrophoblast, Placenta, vol.21, pp.773-781, 2000.
, Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down's syndrome, J Clin Endocrinol Metab, vol.85, pp.3700-3707, 2000.
, Demonstration of functional cytokine-placental interactions: CSF-1 and GM-CSF stimulate human cytotrophoblast differentiation and peptide hormone secretion, Exp Cell Res, vol.214, pp.46-54, 1994.
, Cadherin-11 modulates the terminal differentiation and fusion of human trophoblastic cells in vitro, Dev Biol, vol.257, pp.41-54, 2003.
, Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells, J Biol Chem, vol.267, pp.4479-4488, 1992.
, Human Chorionic Gonadotropin expression in human trophoblasts from early placenta: comparative study between villous and extravillous trophoblastic cells, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00000052
, The physiology of placental lactogen in human pregnancy, Endocrinology, vol.12, pp.329-336, 1991.
, Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG-R complementary DNA, Mol Endocrinol, vol.6, pp.2210-2218, 1992.
, Evidence that human chorionic gonadotropin/luteinizing hormone receptor down-regulation involves decreased levels of receptor messenger ribonucleic acid, Endocrinology, vol.128, pp.388-393, 1991.
, Linkage of human chorionic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis, Placenta, vol.6, pp.163-172, 1985.
, Hormonal regulation of LH receptor mRNA and expression in the rat ovary, FEBS Lett, vol.274, pp.181-184, 1990.
, Preparation of iodine-131 labeled human growth hormone of high specific activity, Nature, vol.194, pp.495-496, 1962.
, Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro, J Cell Sci, vol.111, pp.995-1004, 1998.
, Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae, Endocrinology, vol.118, pp.1567-1582, 1986.
, Gonadotropin-induced up-and downregulation of rat ovarian LH receptor message levels during follicular growth, ovulation and luteinization, Endocrinology, vol.126, pp.3277-3279, 1990.
, Gonadotropin receptors in human fetoplacental unit: implications for hCG as an intracrine, paracrine and endocrine regulator of human fetoplacental function, Troph. Res, vol.6, pp.213-224, 1992.
, Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domain, Science, vol.245, pp.525-533, 1989.
, Loss of lutropin/human choriogonadotropin receptor messenger ribonucleic acid during ligand-induced down-regulation occurs post transcriptionally, Endocrinology, vol.132, pp.235-275, 1993.
, Expression of the Fusogenic HERV-FRD Env Glycoprotein (Syncytin 2) in Human Placenta is Restricted to Villous Cytotrophoblastic Cells, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00000051
, Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family, Science, vol.245, pp.494-503, 1989.
, Luteinizing hormone/human chorionic gonadotropin receptors in breast cancer, Cancer Res, vol.57, pp.857-864, 1997.
, Morphogenesis of syncytiotrophoblast in vivo: an autoradiographic demonstration, Science, vol.141, pp.350-351, 1963.
, Cloning and sequencing of human LH/hCG receptor cDNA, Biochem Biophys Res Commun, vol.172, pp.1049-1054, 1990.
, Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta, J Clin Endocrinol Metab, vol.65, pp.1282-1290, 1987.
, Transforming growth factor beta 1 inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion, 1991.
, Endocrinology, vol.129, pp.22-26
, LIGAND: A versatile computerized approach for characterization of ligand-binding systems, Anal Biochem, vol.107, pp.220-239, 1980.
, Secretion of chorionic gonadotropin from human trophoblasts, Placenta, vol.18, pp.237-241, 1997.
, In situ hybridization of luteinizing hormone/human chorionic gonadotropin receptor messenger ribonucleic acid during hormoneinduced down-regulation and the subsequent recovery in rat corpus luteum, Endocrinology, vol.135, pp.1044-1051, 1994.
, Glycoprotein hormones: structure and function, Annu Rev Biochem, vol.50, pp.465-495, 1981.
, Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface, J Biol Chem, vol.280, pp.26622-26629, 2005.
, The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua, J Clin Endocrinol Metab, vol.70, pp.421-430, 1990.
, Studies of placental morphogenesis I. Radioautographic studies of human placenta utilizing tritiated thymidine, Proc Soc Exp Biol Med, vol.106, pp.829-831, 1961.
, Insulin and glucose do not affect the glycogen content in isolated and cultured trophoblast cells of human term placenta, J Clin Endocrinol Metab, vol.73, pp.888-893, 1991.
, The lutropin/choriogonadotropin receptor, Endocr Rev, vol.14, pp.324-347, 1993.
, Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization, Mol Endocrinol, vol.4, pp.1856-1865, 1990.
, Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts, Endocrinology, vol.132, pp.1387-1395, 1993.
, Monoclonal antibodies against luteinizing hormone receptor. Immunochemical characterization of the receptor, Endocrinology, vol.127, pp.2090-2098, 1990.
, The central role of human chorionic gonadotropin in the formation of human placental syncytium, Endocrinology, vol.144, pp.1108-1120, 2003.
, Evidence for the direct involvement of transmembrane region 6 of the lutropin/choriogonadotropin receptor in activating Gs, J Biol Chem, vol.272, pp.14586-14591, 1997.
, Novel cyclic adenosine 3',5'-monophosphate response element in the human chorionic gonadotropin beta-subunit gene, Mol Endocrinol, vol.5, issue.5, pp.693-702, 1991.
, Placental steroid hormone biosynthesis in primate pregnancy, Endocr Rev, vol.11, pp.124-150, 1990.
, Increase in epidermal growth factor receptor and its messenger ribonucleic acid levels with differentiation of human trophoblast cells in culture, J Cell Physiol, vol.154, pp.122-128, 1993.
, Parathyroid hormone increases epidermal growth factor receptors in cultured human trophoblastic cells from early and term placenta, J Clin Endol Metab, vol.73, pp.288-294, 1991.
, Hypoxia impairs cell fusion and differentiation process in human cytotrophoblast, in vitro, J Cell Physiol, vol.168, pp.346-353, 1996.
, Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling, Endocrinology, vol.140, pp.1775-1782, 1999.
, Cyclic AMP and phorbol ester interact synergistically to regulate the expression of the chorionic gonadotropin genes, Endocrinology, vol.124, pp.1956-1964, 1988.
, Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidence in vivo and in vitro, J Cell Sci, vol.99, pp.681-692, 1991.
, Characterization of sevral clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses, pp.88-95, 1981.
, Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells.Fate of the hormone subunits, J Biol Chem, vol.257, pp.13306-13311, 1982.
, Lysosomal accumulation of the hormone-receptor complex during receptor-mediated endocytosis of human choriogonadotropin, J Cell Biol, vol.99, pp.1242-1250, 1984.
, The lutropin/choriogonadotropin receptor, a 2002 perspective, Endocr Rev, pp.141-174, 2002.
, On the structure of the luteinizing hormone/chorionic gonadotropin receptor, Endocr Rev, vol.10, issue.1, pp.27-44, 1989.
, Structure of human luteinizing hormone-choriogonadotropin receptor gene: unusual promoter and 5' non-coding regions, Mol Cell Endocrinol, pp.113-123, 1995.
, Isolation and characterization of N-and O-glycosidic carbohydrate units of human chorionic gonadotropin, Biochem Biophys Res Commun, vol.84, pp.667-676, 1978.
, A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies, Reprod Biol Endocrinol, vol.3, pp.25-39, 2005.
, Pathology of the human placenta, pp.22-70, 2000.
, Abortion, placenta of trisomies, and immunological considerations of recurrent reproductive failure, p.p, 1993.
, Transforming growth factor beta: Structure, effets biologiques et mécanismes d'action, Bull Cancer, vol.81, pp.1014-1022, 1994.
, Leydig-cell agenesis: a cause of male pseudohermaphroditism, N Engl J Med, vol.295, pp.969-972, 1976.
, Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling, Mol Endocrinol, vol.10, pp.1147-1159, 1996.
, Site-specific processing of the N-linked oligosaccharides of the human chorionic gonadotropin alpha subunit, J Biol Chem, vol.264, pp.17113-17118, 1989.
, Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblasts, Mol hum reprod, vol.10, pp.734-742, 1995.
, Mechanisms of endometrial control of trophoblast invasion, J Reprod Fertil Suppl, vol.55, pp.65-71, 2000.
, Antibody reaction patterns in first trimester placenta: implications for trophoblast isolation and purity screening, Placenta, vol.21, pp.733-741, 2000.
, An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor, J Virol, vol.74, pp.3321-3329, 2000.
, Molecular tinkering protein-coupled recetors: an evolutionary success, EMBO J, vol.18, pp.1723-1729, 1999.
, Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities, Prenat Diagn, vol.7, pp.623-630, 1987.
, Post-translational processing in the Golgi plays a critical role in the trafficking of the luteinizing hormone/human chorionic gonadotropin receptor to the cell surface, J Biol Chem, vol.272, pp.5921-5926, 1997.
, A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, pp.248-254, 1976.
, Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity, EMBO J, vol.10, pp.1885-1890, 1991.
, Serum human chorionic gonadotropin levels throughout normal pregnancy, Am J Obstet Gynecol, pp.678-681, 1976.
, Placental expression of alpha and beta subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome, Hum Reprod, vol.10, pp.2506-2509, 1995.
, Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited, Am J Obstet Gynecol, vol.181, pp.718-724, 1999.
, Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndrome, Br J Obstet Gynaecol, vol.95, pp.330-333, 1988.
, Hypoxiainducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3), J Clin Invest, vol.105, pp.577-587, 2000.
, Why is there a peak of human chorionic gonadotrophin (HCG) in early pregnancy?, Hum Reprod, vol.10, issue.7, pp.1837-1840, 1995.
, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction, Anal Biochem, vol.162, pp.156-159, 1987.
, Hyperglycosylated hCG, a potential alternative to hCG in Down syndrome screening, Prenat Diagn, vol.18, pp.926-933, 1998.
, Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: A new basis for gestational Down syndrome screening, Clin Chem, vol.45, issue.12, pp.2109-2119, 1999.
, Molecular basis of the specificity of binding of glycoprotein hormones to their receptors, Endocr Rev, vol.13, issue.4, pp.670-691, 1992.
, Biochimie des communications cellulaires. Hormones neuromédiateurs cytokines facteurs de croissance, 1994.
, Involvement of gap junctional communication and connexin expression in trophoblast differentiation of the human placenta, Histol Histopathol, vol.16, pp.285-295, 2001.
, Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin, Endocrinology, vol.135, pp.402-408, 1994.
, Requirement of Gap Junctional Intercellular Communication for Human Villous Trophoblast Differentiation, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-02556169
, Oestradiol stimulates morphological and functional differentiation of human villous cytotrophoblast, Placenta, vol.20, pp.669-676, 1999.
, Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome, Prog Clin Biol Res, vol.360, pp.263-280, 1990.
, Segmental trisomy as a mouse model for Down syndrome, Prog Clin Biol Res, vol.384, pp.117-133, 1993.
, Reactive oxygen species and their contribution to pathology in Down syndrome, Adv Pharmacol, vol.38, pp.379-402, 1997.
, Binding specificity of cyclic adenosine 3',5'-monophosphate-responsive element (CRE)-binding proteins and activating transcription factors to naturally occurring CRE sequence variants, Mol Endocrinol, vol.5, issue.10, pp.1541-1551, 1991.
, High maternal serum chorionic gonadotropin level in Downs' syndrome pregnancies is caused by elevation of both subunits messenger ribonucleic acid level in trophoblasts, J Clin Endocrinol Metab, vol.80, pp.3528-3531, 1995.
, Carbohydrate and peptide structure of the alpha-and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma, Endocrine, vol.7, issue.1, pp.15-32, 1997.
, Defaut de differenciation du trophoblaste dans la trisomie 21, Bull Acad Natl Med, issue.184, pp.1033-1047, 2000.
, Transfected cells express mostly the intracellular precursor of the lutropin/choriogonadotropin receptor but this binds choriogonadotropin with high affinity, Biochemistry, vol.37, pp.664-672, 1998.
, Theroretical study on the electrostatically driven step of receptor-G protein recognition, Proteins Struct Funct Genet, vol.37, pp.145-156, 1999.
, Increase in expression and activity of thrombomodulin in term human syncytiotrophoblast microvili, Placenta, vol.4, pp.261-268, 1998.
, Bromo-3', 5'-adenosine monophosphate stimulates the endocrine activity of human cytotrophoblasts in culture, J Clin Endocrinol Metab, vol.8, pp.1211-1217, 1986.
, Novel covalent chaperone complexes associated with human chorionic gonadotropin ? subunit folding intermediates, J Biol Chem, vol.271, pp.18543-18548, 1996.
, Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling, Pharmacol Rev, vol.53, pp.1-24, 2001.
, Oxygen radicals and signaling, Current Opinion in Cell Biology, vol.10, issue.2, pp.248-253, 1998.
, Oxygen and living processes: an interdisciplinary approach, 1982.
, Desensitization of G protein-coupled receptors, Rec Prog Horm Res, vol.51, pp.319-353, 1996.
, Involvement of connexin 43 in human trophoblast cell fusion and differentiation, J Cell Sci, vol.116, pp.3413-3421, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128436
, Trophoblast Production of a Weakly Bioactive Human Chorionic Gonadotropin in Trisomy 21-Affected Pregnancy, J Clin Met Endocrinol, vol.89, pp.727-732, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-00128419
, Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation, Mol Cell Biol, vol.23, pp.3566-3574, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128429
, Implication of copper zinc superoxide dismutase (SOD-1) in human placenta development, Ann N Y Acad Sci, vol.973, pp.297-301, 2002.
, Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation, Endocrinology, vol.142, pp.3638-3648, 2001.
URL : https://hal.archives-ouvertes.fr/inserm-00128447
, Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down syndrome, J Clin Endocrinol Metab, vol.85, pp.3700-3707, 2000.
URL : https://hal.archives-ouvertes.fr/inserm-00128454
, Superoxide anion radical (O2-.), superoxide dismutases, and related matters, Journal of Biological Chemistry, vol.272, pp.18515-18517, 1997.
, The human luteinizing hormone receptor gene promoter: activation by sp1 and sp3 and inhibitory regulation, Biochem Biophys Res Commun, vol.263, pp.366-371, 1999.
, Uncovering molecular mechanisms involved in activation og G protein-coupled receptors, Endocr Rev, vol.21, pp.90-113, 2000.
, Molecular biology of pituitary gonadotropines, Endocr Rev, vol.11, pp.177-179, 1990.
, Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L cells, J Cell Biol, vol.118, pp.1347-1358, 1992.
, A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene, Mol Endocrinol, vol.17, issue.1, pp.11-26, 2003.
, GnRH in pregnancy, Arch Gynecol Obstet, vol.259, issue.1, pp.1-6, 1996.
, Differential processing of Asn-linked oligosaccaharides on pituitary glycoproyein hormones: implications of biologic function, Mol cell biochem, vol.72, pp.81-100, 1986.
, Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phophoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells, J Biol Chem, pp.4479-4488, 1992.
, The physiology of placental lactogen in human pregnancy, Endocrinology, vol.12, pp.329-336, 1991.
, molecular structures of glycoprotein hormones and functions of their carbohydrate components, Biochem J, vol.287, pp.665-679, 1992.
, The imprecision in rates of Down syndrome by 1-year maternal age intervals: a critical analysis of rates used in biochemical screening, Prenat Diagn, vol.14, issue.8, pp.729-738, 1994.
, Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C, J Biol Chem, vol.271, pp.16764-16772, 1996.
, Hormonal and biochemical disturbances in Down's syndrome, J Ment Defic Res, vol.35, pp.179-193, 1991.
, Identification and characterization of a luteinizing hormone/chorionic (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA, Mol Endocrinol, vol.6, pp.2210-2218, 1992.
, Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor expressed in a stably transfected cell line, Mol Endocrinol, vol.7, pp.823-832, 1993.
, Human chorionic gonadotropin-and phorbol ester stimulated phosphorylation of the LH/CG receptor maps to serine 635, 639, 645, and 652 in the Cterminal cytoplasmic tail, Mol Endocrinol, vol.9, pp.151-158, 1995.
, MA-10 cells transfected with the human lutropin/choriogonadotropin receptor (hLHR): a novel experimental paradigm to study the functional properties of the hLHR, pp.1026-1035, 2002.
, Evidence that human chorionic gonadotropin/luteinizing hormone receptor-down regulation involves decreased levels of receptor messenger ribonucleic acid, Endocrinology, vol.128, pp.338-393, 1991.
, The amino-terminal region of the luteinizing hormone/choriogonadotropin recepror contacts both subunits of human choriogonadotropin. I. Mutational analysis, J Biol Chem, vol.273, pp.13835-13840, 1998.
, Gonadal function in patients with Down syndrome, Am J Med Genet, vol.27, issue.2, pp.449-458, 1987.
, Hormonal regulation of LH receptor mRNA and expression in the rat ovary, FEBS Lett, vol.274, issue.1-2, pp.181-184, 1990.
, Preparation of iodine-131 labelled human growth hormone of high specific activity, pp.495-496, 1962.
, Domain-dependent protein folding is indicated by the intracellular kinetics of disulfide bond formation of human chorionic gonadotropin ?-subunit, J Biol Chem, vol.267, pp.21396-21403, 1992.
, Effects of epidermal growth factor, phorbol myristate acetate, and arachidonic acid on choriogonadotropin secretion by cultured human choriocarcinoma cells, a. Endocrinology, vol.116, pp.2400-2409, 1985.
, Molecular insights into the structure and function of human chorionic gonadotropin, J Mol Endo, vol.10, pp.217-234, 1993.
, Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts, Science, vol.275, pp.1649-1652, 1997.
, Effects of diacylglycerol and gonadotropin-releasing hormone on human chorionic gonadotropin release by cultured trophoblast cells, Placenta, vol.13, pp.213-221, 1992.
, Isolation and characterization of the human chorionic gonadotropin ? subunit (CG ?) gene cluster: regulation of transcriptionally active CG? gene by cyclic AMP, Mol cell biol, vol.8, pp.5100-5107, 1988.
, HCG concentration and receptor gene expression in placental tissue from trisomy 18 and 21, Mol Hum Reprod, vol.6, pp.5-10, 2000.
, Asp383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production, J Biol Chem, vol.266, pp.14953-14957, 1991.
, Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes a G-protein modulation and a potential second hormone binding site, Endocrinology, vol.128, pp.2648-2650, 1991.
, Receptor activation of and signal generation by the lutropin/choriogonadotropin receptor, J Biol Chem, vol.268, pp.22971-22974, 1993.
, Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions, Structure, vol.15, pp.1341-1353, 1995.
, Regulation of the human chorionic gonadotropin alpha-and beta-subunit promoters by AP-2, J Biol Chem, vol.272, issue.24, pp.15405-15412, 1997.
, Biomarkers of oxidative stress are significantly elevated in Down syndrome, Free Radical Biol Med, vol.25, pp.1044-1048, 1998.
, Modeling of the three dimensional structure of proteins with the typical leucine rich repeats, Structure, vol.3, pp.867-877, 1995.
, Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein, J Biol Chem, vol.273, pp.10658-10664, 1998.
, Sequence-specific binding of a hormonally regulated mRNA binding protein to cystidine-rich sequences in the lutropin receptor open reading frame, Biochemistry, vol.38, pp.16889-16897, 1999.
, Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia, Biol Reprod, vol.1, pp.1-7, 2003.
, Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells, J Biol Chem, vol.269, pp.664-672, 1994.
, Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro, J Cell Sci, vol.111, pp.995-1004, 1998.
, Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin, J Biol Chem, vol.254, pp.7909-7914, 1979.
, Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat lutropin receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway, Mol Endocrinol, vol.15, pp.1624-1635, 2001.
, Purification, characterization, and in vitro differenciation of cytotrophoblasts from human term placentae, Endocrinology, vol.118, pp.1567-1582, 1986.
, Transcriptional regulation of the human chorionic gonadotropin beta gene during villous trophoblast differentiation, Endocrinology, vol.145, issue.4, pp.1685-1694, 2004.
, Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts, Endocrinology, vol.141, issue.10, pp.3737-3748, 2000.
, Structure, pathology and function of the N-linked sugar chains of human chorionic gonadotropin, Biochimica et Biophysica Acta, vol.1455, pp.315-326, 1999.
, Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats, Nature, vol.366, pp.751-756, 1993.
, Regulation of N-glycosylation. long term effect of cyclic AMP mediates enhanced synthesis of the dolichol pyrophosphate core oligosaccharide, J Biol Chem, vol.269, pp.8659-8666, 1994.
, Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty, Hum Mol Genet, vol.4, pp.183-188, 1995.
, Human chorionic gonadotropin stimulates thyroid hormone secretion, iodide uptake, organification, and adenosine 3', 5' -monophosphate formation in cultured human thyrocytes, J Clin Endocrinol Metab, vol.79, pp.595-599, 1994.
, Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA, Biochemistry, vol.33, issue.6, pp.1592-1598, 1994.
, The role of receptor kinases and arrestins in G protein-coupled receptor regulation, Annu Rev Pharmacol Toxicol, vol.38, pp.289-319, 1998.
, Gonadotropin-induced up-and downregulation of rat ovarian LH receptor message levels during follicular growth, ovulation and luteinization, Endocrinology, vol.126, pp.3277-3279, 1990.
, Crystal structure of human chorionic gonadotropin, pp.455-461, 1994.
, A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precociuos puberty, J Clin Endocrinol Metab, vol.80, pp.2490-2494, 1995.
, Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty, Proc Natl Acad Sci, vol.92, pp.1906-1910, 1995.
, Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty, Biochem Mol Med, vol.10, pp.192-198, 1996.
, targeted distribution of luteinizing hormone/human chorionic gonadotropin receptor gene, Mol Endocrinol, vol.15, pp.184-200, 2001.
, Gonadotropin receptors in human feto-placental unit: implications for hCG as an intracrine, paracrine and endocrine regulator of human feto-placental function, Trophobl, vol.6, pp.213-222, 1992.
, Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain, Endocrinology, vol.132, pp.2262-2270, 1993.
, Novel co-expression of human chorionic gonadotropin/human luteinizing hormone receptors and their ligand, hCG, in human fallopian tubes, J Clin Endocrinol Metab, vol.77, pp.863-872, 1993.
, Increased expression of human chorionic gonadotropin/human luteinizing hormone receptors in adenomyosis, J Clin Endocrinol Metab, vol.76, issue.3, pp.763-768, 1993.
, Placental structure: in a comparative aspect, Exp Clin Endocrinol, vol.102, pp.122-134, 1994.
, , 1959.
, C R Hebd Seances Acad Sci, vol.248, issue.11, pp.1721-1722
, Intracellular signaling in the gonads, Endocr Rev, vol.13, pp.476-498, 1992.
, Novel self-regulation of human chorionic gonadotropin biosynthesis in term pregnancy human placenta, Endocrinology, vol.133, pp.3014-3025, 1993.
, Leptin production and release in the dually in vitro perfused human placenta, J Clin Endocrinol Metab, vol.11, pp.4298-4301, 2000.
, Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domain, pp.525-528, 1989.
, Loss of lutropin/human choriogonadotropin receptor messenger ribonucleic acid during ligand-induced down-regulation occurs post transcriptionally, Endocrinology, vol.132, pp.235-240, 1993.
, Maternal serum Down syndrome screening: free beta-protein is a more effective marker than human chorionic gonadotropin, Am J Obstet Gynecol, vol.163, pp.1248-1253, 1990.
, A comparison of placental development and endocrine functions between the human and mouse model, Hum Reprod Update, vol.9, issue.6, pp.531-539, 2003.
, Hormones and human trophoblast differentiation, Endocrine, vol.19, 2002.
, Expression of stromelysine-3 in the human implantation placenta site, Placenta, vol.16, p.46, 1995.
, Differential modulation of chorionic gonadotropin (CG) subunit messenger ribonucleic acid levels and CG secretion by progesterone in normal placenta and choriocarcinoma culotured in vitro, Endocrinology, vol.119, pp.855-864, 1986.
, Evain-Brion D. 2001. defect of syncytiotrophoblast formation and hCG expression in Down's syndrome, Placenta, vol.22
, Trophoblast-derived transforming growth factor-?1 suppress cytokine-induced, but not gonadotropin-releasing hormone-induced, release of human chorionic gonadotropin by normal human trophoblasts, J Clin Endocrinol Metab, vol.74, pp.211-216, 1992.
, The role of Asparagine-linked oligosaccharides of the ?-subunit in the secretion and assembly of human chorionic gonadotropin, J Cell Biol, vol.106, pp.1049-1059, 1988.
, Site-specific mutagenesis defines the intracellular role of the Asparagine linked oligosaccharides of chorionic gonadotropin ?-subunit, J Biol Chem, vol.263, pp.17106-17111, 1988.
, The biological role of the carboxyl-terminal extension of human chorionic gonadotropin ?-subunit, Endocrinology, vol.126, pp.376-383, 1990.
, Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction, J Biol Chem, vol.264, pp.2409-2414, 1989.
, Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family, Science, vol.245, pp.494-499, 1989.
, Luteinizing hormone/human chorionic gonadotropin receptors in breast cancer, Cancer Res, vol.57, pp.857-864, 1997.
, An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities, Am J Obstet Gynecol, vol.148, pp.886-894, 1984.
, Evidence for impaired subunit interaction in chemically deglycosylated human choriogonadotropin, Biochem Biophys Res Commun, vol.156, pp.1271-1278, 1988.
, The primate placenta and human chorionic gonadotropin, Exp Clin Endocrinol, vol.102, pp.222-234, 1994.
, Biosynthesis of human chorionic gonadotropin: a review, Eur J Endocrinol, vol.135, issue.3, pp.269-284, 1996.
, Ca2+ entry through L -Type voltage semsitive Ca2+ channels stimulates the release of human chorionic gonadotrophin and placental lactogen by placental explants, Biochimica et Biophysica Acta, vol.1220, pp.101-106, 1994.
, Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis, Nature, vol.403, pp.785-789, 2000.
, Morphogenesis of syncytiotrophoblast in vivo: an autoradiographic demonstration, Science, vol.141, pp.350-351, 1963.
, Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agoniststimulated internalization of the lutropin/choriogonadotropin receptor, J Biol Chem, vol.273, pp.34911-34919, 1998.
, Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor, Mol Endocrinol, vol.14, pp.1797-1810, 2000.
, The association of arrestin-3 with the human lutropin/choriogonadotropin receptor depends mostly on receptor activation rather than on receptor phosphorylation, J Biol Chem, vol.277, pp.702-710, 2002.
, Cloning and sequencing of human LH/hCG receptor cDNA, Biochem Biophys Res Commun, vol.172, pp.1049-1054, 1990.
, Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta, J Clin Endocrinol Metab, pp.1282-1290, 1987.
, Transforming growth factor ?1 inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion, Endocrinology, vol.129, pp.22-26, 1991.
, Functional regulation of human trophoblast differentiation, J Reprod Immunol, vol.39, pp.179-195, 1998.
, Demonstration of specific secretory granules for human chorionic gonadotropin in placenta, J Histochem Cytochem, vol.35, pp.93-101, 1987.
, Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of glycoprotein hormones, J Biol Chem, vol.270, 1995.
, First-trimester screening for Down syndrome in France combining fetal nuchal translucency measurement and biochemical markers, Prenat Diagn, vol.23, issue.10, pp.833-836, 2003.
, Secretion of chorionic gonadotropin from human trophoblasts, Placenta, vol.18, pp.237-241, 1997.
, The carboxy-terminal region of the ? subunits of luteinizing hormone and chorionic gonadotropin differentially secretion and assembly of the heterodimers, Mol Endocrinol, vol.10, pp.1678-1687, 1996.
, Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region, J Biol Chem, vol.275, pp.30264-30271, 2000.
, A dileucine-based motif in the C-terminal tail of the lutropin/choriogonadotropin receptor inhibits endocytosis of the agonist-receptor complex, Mol Pharmacol, vol.56, pp.728-736, 1999.
, Role of the rate of internalization of the agonist-receptor complex on the agonist-induced down-regulation of the lutropin/choriogonadotropin receptor, Mol Endocrinol, vol.13, pp.1295-1304, 1999.
, The rate of internalization of the gonadotropin receptors is greatly affected by the origi of the extracellular domain, J Biol Chem, vol.274, pp.1902-1912, 1999.
, Seven non-contiguous intra-cellular residues of the lutropin/choriogonadotropin receptor dictate the rate of agonist-induced internalization and its sensitivity to non-visual arrestins, J Biol Chem, vol.275, pp.241-247, 2000.
, Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse, Somatic Cell Genet, pp.757-770, 1983.
, Enzymic remodelling of the Nand O-linked carbohydrate chains of human chorionic gonadotropin. Effects on biological activity and receptor binding, Eur J Biochem, vol.227, issue.3, pp.880-888, 1995.
, The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the tranmembrane region: studies using chimeric human and fly receptors, J Biol Chem, vol.277, pp.3958-3964, 2001.
, hCGbeta core fragment is a metabolite of hCG: evidence from infusion of recombinant hCG, J Endocrinol, vol.164, issue.3, pp.299-305, 2000.
, Le placenta des Trisomie 21 dans le dernier trimestre de la gestation, J Gynecol Obstet Biol Reprod, vol.12, pp.345-349, 1983.
, The placenta as an endocrine organ: polypeptides, Physiology of reproduction, pp.875-945, 1994.
, Growth factors, protooncogènes and human placental development, Cell Diff Dev, vol.28, pp.1-16, 1989.
, Derivation of functional antagonists using N-terminal extracellular domain of the extracellulaire domain of the thyrotropin receptors, Mol Endocrinol, vol.11, pp.1659-1668, 1997.
, Crystal structure of rhodopsin: A G proteincoupled receptor, Science, vol.289, pp.739-745, 2000.
, In situ hybridization of luteinizing hormone/human chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization, Mol Endocrinol, vol.4, pp.1856-1865, 1994.
, O-glycosylation of the ?-subunit does not limit the assembly of chorionic gonadotropin ?? dimer in human malignant and non malignant trophoblast cells, Endocrinology, vol.124, pp.1602-1612, 1989.
, Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth, Endocrinology, vol.143, issue.8, pp.3114-3121, 2002.
, Biochemical characterization and modulation of LH/CGreceptor during human trophoblast differentiation, J Cell Physiol, 2006.
, Impact of trisomy 21 on human trophoblast behaviour and hormonal function, Placenta, vol.25, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-02556164
, Glycoprotein hormones: structure and function, Annu Rev Biochem, pp.465-495, 1981.
, G protein-coupled receptor kinases, Annu Rev Biochem, vol.67, pp.653-692, 1998.
, The release of human chorionic gonadotrophin and placental lactogen by placental explants can be stimulated by Ca2+ entry through a Na+ -Ca2+ exchange process, Placenta, vol.15, pp.477-485, 1994.
, Thyroid function in Down syndrome, Res Dev Disabil, vol.12, issue.3, pp.287-296, 1991.
, The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors, Mol Endocrinol, vol.7, pp.767-775, 1993.
, Luteinizing hormone/choriogonadotropin receptor-mediated activation of heterotrimeric guanine nucleotide binding proteins in ovarian follicular membranes, Endocrinology, vol.139, pp.4547-4555, 1998.
, The begining of a new era in reproductive biology and medicine: expression of low levels of functional luteinizing hormone/human chorionic gonadotropin receptors in nongonadal tissues, J Physiol Pharmacol, vol.47, pp.41-53, 1996.
, A paradigm shift on the targets of luteinizing hormone/human chorionic gonadotropin actions in the body, J Bellevue Obstet Gynecol Soc, vol.15, pp.26-32, 1999.
, Novel expression of functional human chorionic gonadotropin/luteinizing hormone receptor gene in umbilical cords, J Clin Endocrinol Metab, vol.77, pp.1706-1714, 1993.
, Receptors for gonadotropins in human ovaries, Prog Clin Biol Res, vol.112, pp.123-135, 1982.
, Down's syndrome. A complicated genetic insult, Lancet, vol.358, p.23, 2001.
, Oxidative processes and antioxidative defense mechanisms in the aging brain, FASEB J, vol.9, pp.526-533, 1995.
, The presence of gonadotropin receptors in nonpregnant human uterus, human placental, fetal membranes, and decidua, J Clin Endocrinol Metab, vol.70, issue.2, pp.421-430, 1990.
, Studies of placental morphogenesis I. Radioautographic studies of human placenta utilizing tritiated thymidine, Proc Soc Exp Biol Med, vol.106, pp.829-831, 1961.
, Hormonal control of gene expression in the ovary, Endocr Rev, vol.15, pp.725-751, 1994.
, Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice, Dev Dyn, vol.217, issue.2, pp.137-145, 2000.
, Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome, Am J Med Genet, vol.107, issue.4, pp.317-324, 2002.
, Regulation of human trophoblast function by glucocorticoids: dexamethasone promotes increased secretion of chorionic gonadotropin, Endocrinology, vol.124, pp.1625-1631, 1989.
, In vitro systems for the study of human placental endocrine function, Endocr Rev, vol.1, pp.105-123, 1990.
, A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells, J Biol Chem, vol.276, issue.13, pp.10016-10024, 2001.
, Histomorphological features of chorionic vill at 10-14 weeks of gestation in trisomic and chromosomally normal pregnancies, Placenta, vol.21, pp.678-683, 2000.
, Trophoblast gene expression: transcription factors in the specification of early trophoblast, Reprod Biol Endocrinol, vol.2, p.47, 2004.
, Evidences for an allelic variant of the human LH/CG receptor rather than a gene duplication: functional comparison of wild-type and variant receptors, J Clin Endocrinol Metab, pp.4431-4434, 1998.
, Response to challenge with gonadotropin-releasing hormone agonist in a mother and her two sons with a constitutively activating mutation of the luteinizing hormone receptor, J Clin Endocrinol Metab, vol.81, pp.3802-3806, 1996.
, The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene, pp.222-224, 1993.
, Localization of the human luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chromosome 2p21, Cytogenet Cell Genet, pp.77-79, 1990.
, Assignment of the human tyroid stimulating hormone receptor (TSHR) gene to chromosome 14q31, Genomics, pp.233-236, 1990.
, Association of gonadotropin receptor precursors with the protein folding chaperone calnexin, Endocrinology, vol.139, pp.1588-1593, 1998.
, Characterization of the intracellular and secreted forms of the glycoprotein hormone chorionic gonadotropin produced by human malignant cells, J Biol Chem, vol.256, pp.5189-5196, 1981.
, B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins, Oncogene, vol.6, issue.4, pp.533-542, 1991.
, Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities, Proc Natl Acad Sci U S A, vol.95, issue.11, pp.6256-6261, 1998.
, Role of carbohydrates in glycoprotein hormone signal transduction, FASEB J, vol.3, pp.1915-1926, 1989.
, Comparison of the biological and immunological properties of glycosylation deficient human chorionic gonadotropin variants produced by site directed mutagenesis and chemical deglycosylation, Mol Cell Endocrinol, vol.85, issue.3, pp.227-235, 1992.
, A role for oxygen free radicals as second messengers, Trends in Cell Biology, vol.1, pp.39-42, 1991.
, Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization, Mol Endocrinol, vol.4, pp.1856-1865, 1990.
, A constitutively mutation of the luteinizing hormone receptor in familial male precocious puberty, Nature, vol.365, pp.652-654, 1993.
, Norepinephrine regulates human chorionic gonadotropin production by first trimester trophoblast tissue in vitro, Placenta, vol.14, pp.683-693, 1993.
, Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts, endocrinology, vol.132, pp.1387-1395, 1993.
, Transforming growth factor-?1 in reproduction and developpment, Mol Reprod Dev, vol.39, pp.239-246, 1994.
, Bromo-adenosine stimulates choriogonadotropin production in Jar and cytotrophoblast cells: evidence for effect on two stage of differentiation, Mol Endocrinol, vol.5, pp.582-586, 1991.
, Trisomy 21 and superoxide dismutase-1 (IPO-A). Tentative localization of sub-band 21Q22.1, Exp Cell Res, vol.97, pp.47-55, 1976.
, Hormone interactions to Leu-rich repeats in the gonadotropin receptors. I. Analysis of Leu-rich repeats of human luteinizing hormone/chorionic gonadotropin receptor and follicule-stimulating hormone receptor, J Biol Chem, vol.276, pp.3426-3435, 2001.
, Coordinate control of the alpha-and beta-subunit genes of human chorionic gonadotropin by trophoblast-specific element-binding protein, Mol Endocrinol, vol.7, issue.12, pp.1579-1588, 1993.
, GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland, Mol Cell Biol, vol.14, issue.8, pp.5592-5602, 1994.
, Luteinizing hormone action and receptors, Structure of LH and hCG. In: Ascoli M, p.p, 1985.
, Human term placenta contains transforming growth factors, Biochem Biophys Res Commun, vol.106, pp.354-361, 1982.
, Analysis of hCG: clinical applications and assay requirements, Ann Clin Biochem, vol.35, pp.460-491, 1998.
, The human genome contains seven genes for the betasubunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone, pp.281-289, 1983.
, Evolution of the beta subunits of human chorionic gonadotropin and luteinizing hormone, Nature, pp.37-40, 1984.
, Deglycosylation of the human luteinizing hormone receptor does not affect ligand binding and signal transduction, Endocrine, vol.1, pp.219-225, 1993.
, Mutationnal analysis of the extracellular domain of the full-length lutropin/ choriogonadotropin receptor suggest leucine rich repeats 1-6 are involved in hormone binding, Mol Endocrinol, vol.10, pp.760-768, 1996.
, Direct novel regulation of cyclooxygenase and prostacyclin synthetase by human chorionic gonadotropin in the human amnion, Trophobl, vol.8, pp.503-514, 1994.
, Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity, J Biol Chem, vol.265, pp.19385-19388, 1990.
, A novel human luteinizing hormone receptor gene, J Clin Endocrinol Metab, pp.288-291, 1998.
, Human chorionic gonadotropin beta-core fragment is present in the human placenta, Mol Cell Endocrinol, vol.139, issue.1-2, pp.171-178, 1998.
, Immunological and biological activity of hCG following progressive desialylation, Endocrinology, vol.88, pp.456-464, 1971.
, Monoclonal antibodies against luteinizing hormone receptor. Immunochemical characterization of the receptor, pp.2090-2098, 1990.
, Variant forms of the pig lutropin/choriogonadotropin receptor, Biochemistry, vol.31, pp.8377-8383, 1992.
, The fusion of myoblasts, Biochem J, vol.15, pp.1-12, 1985.
, Maternal serum unconjugated oestriol as an antenatal screening test for Down's syndrome, Br J Obstet Gynaecol, vol.95, pp.334-341, 1988.
, Lutropin/choriogonadotropin down-regulates its receptor by both receptor mediated endocytosis and a cAMP-dependent reduction in receptor mRNA, J Biol Chem, vol.266, pp.780-785, 1991.
, Progressive cytoplasmic tail truncations of the lutropinchoriogonadotropin receptor prevent agonist-or phorbol ester-induced phosphorylation, impair agonist or phorbol ester-induced desensitization and enhance agonist-induced receptor down-regulation, Mol Endocrinol, vol.10, pp.748-759, 1996.
, Phophorylation of the lutropin/choriogonadotropin receptor facilitates uncoupling of the receptor from adenylyl cyclase and endocytosis of the bound hormone, Mol Endocrinol, vol.11, pp.183-192, 1997.
, Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro, Exp Cell Res, pp.306-316, 1990.
, Mechanism of activation of the TGF? receptor, Nature, vol.70, pp.341-347, 1994.
, Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein, pp.545-558, 1994.
, Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity, J Biol Chem, vol.265, pp.21411-21414, 1990.
, Human chorionic gonadotropin secretion and protein phosphorylation in chorionic tissue, Endocrine, vol.41, pp.509-516, 1994.
, The central role of human chorionic gonadotropin in the formation of human placental syncytium, Endocrinology, vol.144, pp.1108-1120, 2003.
, A sporadic case of male-limited precocious puberty has the same constitutively activating point mutation in luteinizing/choriogonadotropin receptor gene as familial cases, J Clin Endocrinol Metab, vol.79, pp.1818-1823, 1994.
, Monocytes from circulating blood fuse in vitro with purified osteoclasts in primary culture, J Cell Sci, vol.66, pp.335-342, 1984.
, Initiation of transcription by RNA polymerase II: a multi-step process, Prog Nucleic Acid Res Mol Biol, vol.44, pp.67-108, 1993.
, The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation, J Biol Chem, vol.276, pp.3451-3458, 2001.
, The unique exon 10 of the human luteinizing hormone receptor is necessary for expression of the receptor protein at the plasma membrane in the human luteinizing hormone receptor, but deleterious when inserted in the human follicle-stimulating hormone receptor, Mol Cell Endocrinol, vol.142, pp.165-174, 1998.
, Cloning and functional expression of the luteinizing hormone receptor complementary deoxyribonucleic acid from the marmoset monket testis: absence of sequences encoding exon 10 in other species, pp.2481-2490, 1997.
, Requirement of cysteine residues in exons 1-6 of the extracellular domain of the luteinizing formine receptor for gonadotropin binding, J Biol Chem, vol.271, pp.5775-5760, 1996.
, Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor, J Biol Chem, vol.275, pp.2763-2767, 2000.
, EAR2 and EAR3/COUP-TF1 regulate transcription of the rat LH receptor, Mol Endocrinol, vol.15, pp.1891-1905, 2001.
, Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex, J Biol Chem, vol.277, issue.36, pp.33431-33438, 2002.
, Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB, Mol Cell Biol, vol.23, pp.6958-6972, 2003.
, The lutropin/choriogonadotropin (LH/CG) receptor is palmitoylated at intracellular cysteine residues, Mol Endocrinol, vol.9, pp.141-150, 1995.
, Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density, Mol Pharmacol, vol.46, pp.460-469, 1994.
, Human myometrial chorionic gonadotropin/luteinizing hormone receptors in preterm and term deliveries, J Clin Endocrinol Metab, vol.79, pp.907-911, 1994.
, Characterization of human chorionic gonadotropin as a novel angiogenic factor, J Clin Endocrinol Metab, vol.87, pp.5290-5296, 2002.
, ANNEXE
, 0143-4004/$-see front matter 2004 IFPA and, Trophoblast Research, vol.25, pp.79-84, 2004.
, Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation, Br J Obstet Gynaecol, vol.102, pp.957-62, 1995.
, Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities, Prenat Diagn, vol.7, pp.623-653, 1987.
, An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities, Am J Obstet Gynecol, vol.148, pp.886-94, 1984.
, Integrated screening for Down's syndrome on the basis of tests performed during the first and second trimesters, N Engl J Med, vol.341, pp.461-468, 1999.
, Evain-Brion D. Human placental growth hormone, Am J Obstet Gynecol, vol.177, pp.1526-1560, 1997.
, The physiology of placental lactogen in human pregnancy, Endocrinology, vol.12, pp.329-365, 1991.
, Regulation of chorionic gonadotropin gene expression, Endocr Rev, vol.14, pp.203-224, 1993.
, Purification, characterization, and in vitro differenciation of cytotrophoblasts from human term placentae, Endocrinology, vol.118, pp.1567-82, 1986.
, Evain-Brion D. Parathyroid hormone increases epidermal growth factor receptors in cultured human trophoblastic cells from early and term placenta, J Clin Endocrinol Metab, vol.73, pp.288-94, 1991.
, Neonatal and fetal medicine: physiology and pathophysiology
, High maternal serum chorionic gonadotropin level in Downs' syndrome pregnancies is caused by elevation of both subunits messenger ribonucleic acid level in trophoblasts, J Clin Endocrinol Metab, vol.80, pp.3528-3559, 1995.
, Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down syndrome, J Clin Endocrinol Metab, vol.85, pp.3700-3707, 2000.
URL : https://hal.archives-ouvertes.fr/inserm-00128454
, Defect of syncytiotrophoblast formation and hCG expression in Down's syndrome, Placenta, vol.22, pp.93-100, 2001.
, Pathology of the human placenta, pp.22-70, 2000.
, Le placenta des Trisomie 21 dans le dernier trimestre de la gestation, J Gynecol Obstet Biol Reprod, vol.12, pp.345-354, 1983.
, Histomorphological features of chorionic vill at 10-14 weeks of gestation in trisomic and chromosomally normal pregnancies, Placenta, vol.21, pp.678-83, 2000.
, Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation, Endocrinology, vol.142, pp.3638-3686, 2001.
URL : https://hal.archives-ouvertes.fr/inserm-00128447
, Evain-Brion D. Implication of copper zinc superoxide dismutase (SOD-1) in human placenta development, Ann N Y Acad Sci, vol.973, pp.297-301, 2002.
, Antioxidant enzymes in psoriatic fibroblasts and erythrocytes, J Invest Dermatol, vol.106, pp.1325-1333, 1996.
, Trophoblast production of a weakly bioactive human chorionic gonadotropin in trisomy 21-affected pregnancy, J Clin Endocrinol Metab, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128419
, Retinoids stimulate leptin synthesis and secretion in human syncytiotrophoblast, J Clin Endocrinol Metab, vol.85, pp.2550-2555, 2000.
, Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans, Nat Med, vol.3, pp.1029-1062, 1997.
, An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor, J Virol, vol.74, pp.3321-3330, 2000.
, Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis, Nature, vol.403, pp.785-794, 2000.
, Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation, Mol Cell Biol, vol.23, pp.3566-74, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128429
, Requirement of gap junctional intercellular communication for human villous trophoblast differentiation, Biol Reprod, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-02556169
, Involvement of connexin 43 in human trophoblast cell fusion and differentiation, J Cell Sci, vol.116, pp.3413-3434, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128436
, Cadherin-11 modulates the terminal differentiation and fusion of human trophoblastic cells in vitro, Dev Biol, vol.257, pp.41-54, 2003.
, Hypoxia impairs cell fusion and differentiation process in human cytotrophoblast, in vitro, J Cell Physiol, vol.168, pp.346-53, 1996.
, The effect of hypoxia on human trophoblast in culture: morphology, glucose transport and metabolism, Placenta, vol.18, pp.129-165, 1997.
, Hypoxia limits differentiation and up-regulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta, Am J Obstet Gynecol, vol.180, pp.896-902, 1999.
, An ultrastructural and ultrahistochemical study of the placenta in maternal essential hypertension, Placenta, vol.2, pp.193-204, 1981.
, The human placenta in idiopathic intrauterine growth retardation: a light and electron microscopic study, Placenta, vol.4, pp.65-73, 1983.
, Oxygen radicals and signaling, Curr Opin Cell Biol, vol.10, pp.248-53, 1998.
, Trisomy 21 and superoxide dismutase-1 (IPO-A). Tentative localization of sub-band 21Q22.1, Exp Cell Res, vol.97, pp.47-55, 1976.
, The estimation of red cell superoxide dismutase activity by pulse radiolysis in normal and trisomic 21 subjects, FEBS Lett, vol.69, pp.55-63, 1976.
, Superoxide dismutase activities of blood platelet in trisomy 21, Biochem Biophys Res Commun, vol.67, pp.904-913, 1975.
, Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21, Am J Hum Genet, vol.29, pp.563-70, 1977.
, Influence of age on activities of antioxidant enzymes and lipid peroxidation products in erythrocytes and neutrophils of Down syndrome patients, Free Radic Biol Med, vol.31, pp.499-508, 2001.
, Antioxidant enzymes and fatty acid status in erythrocytes of Down's syndrome patients, Clin Chem, vol.44, pp.924-933, 1998.
, Red cell superoxide dismutase, glutathione peroxidase and catalase in Down syndrome patients with and without manifestations of Alzheimer disease, Am J Med Genet, vol.35, pp.459-67, 1990.
, Placental morphogenesis in pregnancies with Down's syndrome might provide a clue to pre-eclampsia, Placenta, vol.23, pp.172-176, 2002.
, Oxygen, early embryonic metabolism and free radical-mediated embryopathies, Reprod Biomed Online, vol.6, pp.84-96, 2003.
, Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia, Placenta, vol.22, pp.206-218, 2001.
, HCG concentration and receptor gene expression in placental tissue from trisomy 18 and 21, Mol Hum Reprod, vol.6, pp.5-10, 2000.
, Biochemical markers of trisomy 21 and the pathophysiology of Down's syndrome pregnancies, Prenat Diagn, vol.17, pp.941-51, 1997.
, Supplement A, Trophoblast Research, vol.25, 2004.
, Studies of placental morphogenesis I. Radioautographic studies of human placenta utilizing tritiated thymidine, Proc Soc Exp Biol Med, vol.106, pp.829-831, 1961.
, Pathology of the Human Placenta, 2000.
, The placenta as an endocrine organ: polypeptides, pp.875-945, 1994.
, Placental metabolism and its regulation in health and diabetes, Molecular Aspects of Medicine, pp.505-682, 1994.
, Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae, Endocrinology, vol.118, pp.1567-1582, 1986.
, Evain-Brion D. Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation, Endocrinology, vol.142, pp.3638-3648, 2000.
, Microarray analysis of trophoblast differentiation: gene expression reprogramming in key gene function categories, Physiol Genomics, vol.17, pp.105-116, 2001.
, Structural and functional diversity of connexin genes in the mouse and human genome, Biol Chem, vol.383, pp.725-737, 2002.
, Gap junctions. Multiplicity of controls in differentiated and undifferentiated cells and possible functional implications, Adv Second Messenger Phosphoprotein Res, vol.27, pp.163-198, 1993.
, The cellular Internet: online with connexins, Bioessays, vol.18, pp.709-718, 1996.
, Connexin genes and cell growth control, Arch Toxicol Suppl, vol.18, pp.105-114, 1996.
, Gap junctions and the regulation of cellular functions of stem cells during development and differentiation, Methods, vol.20, pp.245-264, 2000.
, Is intercellular communication via gap junctions required for myoblast fusion?, Cell Adhes Commun, vol.2, pp.329-343, 1994.
, Involvement of gap junctional communication in myogenesis, Int Rev Cytol, vol.196, pp.1-65, 2000.
, Connexin expression and gap junctional intercellular communication in human first trimester trophoblast, Mol Hum Reprod, vol.8, pp.1005-1013, 2002.
, Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin, Endocrinology, vol.135, pp.402-408, 1994.
, Interaction of anaesthetics with electrical synapses, Nature, vol.286, pp.498-500, 1980.
, Acetylated low density lipoprotein endocytosis by human syncytiotrophoblast in culture, Placenta, vol.11, pp.191-204, 1990.
, Insulin and glucose do not affect the glycogen content in isolated and cultured trophoblast cells of human term placenta, J Clin Endocrinol, vol.73, pp.888-893, 1991.
, Effects of endothelin on villous trophoblast differentiation and free intracellular calcium, Trophobl Res, vol.13, pp.69-86, 1999.
, A fluorescence photobleaching assay of gap junction-mediated communication between human cells, Science, vol.232, pp.525-528, 1986.
, Retinoid receptors expression in human term placenta: involvement of RXRa in retinoid induced-hCG secretion, J Clin Endocrinol Metab, vol.83, pp.1384-1387, 1998.
, Evain-Brion D. Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro, J Cell Sci, vol.111, pp.996-1004, 1998.
, Differentiation of human trophoblast cells in vitro as revealed by immunocytochemical staining of desmoplakin and nuclei, J Cell Sci, vol.96, pp.131-141, 1990.
, The physiology of placental lactogen in human pregnancy, Endocrinology, vol.12, pp.329-336, 1991.
, Advances in bone biology: the osteoclast, Endocr Rev, vol.17, pp.308-332, 1996.
, Bone-resorbing osteoclasts contain gap-junctional connexin-43, J Bone Miner Res, vol.15, pp.919-926, 2000.
, The fusion of myoblasts, Biochem J, vol.228, pp.1-12, 1985.
, Monoclonal antiphosphatidylserine antibody inhibits intercellular fusion of the choriocarcinoma line, Jar. Biol Reprod, vol.53, pp.905-910, 1995.
, Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta, Histochem Cell Biol, vol.110, pp.495-508, 1998.
, Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis, Nature, vol.403, pp.785-789, 2000.
, Junctional intercellular communication: the cell-tocell membrane channel, Physiol Rev, vol.61, pp.829-913, 1981.
, Antibodies to gap junction protein selectively disrupt junctional communication in the early amphibian embryo, Nature, vol.311, pp.127-131, 1984.
, Cardiac malformation in neonatal mice lacking connexin43, Science, vol.267, pp.1831-1834, 1995.
, Connexin43 deficiency caused delayed ossification, craniofacial abnormalities, and osteoblast dysfunction, J Cell Biol, vol.151, pp.931-944, 2000.
, Cell coupling modulates the contraction of fibroblast-populated collagen lattices, J Cell Physiol, vol.184, pp.86-92, 2000.
, Gap junctional channel inhibition alters actin organization and calcium propagation in rat cultured astrocytes, Neuroscience, vol.112, pp.593-603, 2001.
, Mechanism of heptanol-induced uncoupling of cardiac gap junctions: a perforated patch-clamp study, Am J Physiol, vol.262, pp.1531-1538, 1992.
, Effects of n-alcohols on junctional coupling and amylase secretion of pancreatic acinar cells, J Cell Physiol, vol.139, pp.147-156, 1989.
, Mechanisms of syncytial fusion: a review, Placenta, vol.23, pp.107-113, 2002.
, Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation, Mol Cell Biol, vol.23, pp.3566-3574, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00128429
, Evain-Brion D. Nuclear retinoic acid receptor characterization in cultured human trophoblast cells: effect of retinoic acid on epidermal growth factor receptor expression, Mol Cell Endocrinol, vol.105, pp.165-173, 1994.
, Regulation of gap junctional communication during human trophoblast differentiation, Microsc Res Tech, vol.38, pp.21-28, 1997.
, Hormones and human trophoblast differentiation: a review, Endocrine, vol.19, pp.3-10, 2003.
, Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice, J Cell Biol, vol.140, pp.1453-1461, 1998.
, Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation, Dev Biol, vol.231, pp.334-347, 2001.