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IMPLICATION D’UNE FORME D’hCG ANORMALE ET DE SON RÉCEPTEUR (R-LH/CG) DANS LE DÉVELOPPEMENT PLACENTAIRE LORS D’UNE GROSSESSE ASSOCIÉE À UNE TRISOMIE 21

Abstract : In women bearing a trisomy 21 -affected fetus, there are severe abnormalities during the placental development, leading to a defect in the formation and functionality of the syncytiotrophoblast (ST). ST, which arises from fusion and differentiation of cytotrophoblasts (CT), plays an essential role in the maintenance of the pregnancy by transporting the nutrients necessary to fetal development and secreting in maternal blood the placental hormone hCG. In T21-affected pregnancies, CT don't fused properly and the resulting ST secretes an abnormal and weakly bioactive hCG. To better understand the defect of ST formation occurring in placental development of T21 -affected pregnancies, we have studied the functionality and the interaction of the abnormal hCG with its receptor (LH/CG-R). In this study, we describe for the first time that in T21, it exists a severe decrease in the number of mature LH/CG-R expressed at the cell surface and that abnormal secreted hCG can bind to its receptor. Indeed, in T21, decrease of LH/CG-R expression associated with a weakly bioactive hCG may be involved in the ST formation defect as illustrated by the fact that specific inhibition of LH/CG-R expression by siRNA in normal CT mimics the T21 phenotype (defect of ST formation). More interestingly, treatment of T21-affected CT by a normal exogenous hCG reverses the T21 phenotype, allowing CT to fuse and form a functional ST.
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https://www.hal.inserm.fr/tel-02556183
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Submitted on : Monday, April 27, 2020 - 7:08:37 PM
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Guillaume Pidoux. IMPLICATION D’UNE FORME D’hCG ANORMALE ET DE SON RÉCEPTEUR (R-LH/CG) DANS LE DÉVELOPPEMENT PLACENTAIRE LORS D’UNE GROSSESSE ASSOCIÉE À UNE TRISOMIE 21. Sciences du Vivant [q-bio]. Paris 7, 2006. Français. ⟨tel-02556183⟩

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