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, .2'XPC'and'GCN5:'regulation'of'H3K9ac

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, Yellow! Fever! (YFV),! CrimeaOCongo! Hemorrhagic! Fever! (CCHF)! and! Rift! Valley! Fever!

!. Genera!-orthobunyavirus, . Hantavirus, and . Nairovirus, ! Phlebovirus! and! Tospovirus! characterized! by! their! antigenic,! genetic! and! ecological! properties.! Orthobunyaviruses,! nairoviruses! and! phleboviruses! infect! vertebrates! and! are! vectored! by! haematophagous! arthropods! including! mosquitoes

, !on!the! organization!of!chromatin!and!more!globally!the!nucleus!organization,! -Integrate! these! different! viral! mechanisms! and! understand! their! spatial! and! temporal!orchestration!during!the!viral!cycle,! transcriptional! shut!off!due!to,!at!least,!the!relation!between!NSs/TFIIH!for!RVFV!and!NSs/Mediator!for! BUNV.!TFIIH!and!the!Mediator!are!crucial!for!transcription!playing!numerous!functions.! They! can! control! the! phosphorylation! of! RNA! polymerase! II,! the! recruitment! and! the! activity! of! GTFs,! proximal! pausing,! elongation! factors! and! histone! modifying! enzymes! (443,(444).! TFIIH! and! the! Mediator! through! the! NER! factors! and! the! Cohesin! complex! respectively! also! regulate! chromatin! rearrangements, ! -Describe! the! mechanisms! explaining! how! these! interactions! can! lead! to! an! inhibition!of!the!host!RNA!synthesis,!! -Measure!the!impact!of!one!interaction!on!the!genomeOwide!transcription

. !!!,

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