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Méthodes d'analyse génétique de traits quantitatifs corrélés : application à l'étude de la densité minérale osseuse

Abstract : The majority of complex diseases in humans are likely determined by both genetic andenvironmental factors. Using correlated phenotypes may increase the power to map theunderlying Quantitative Trait Loci (QTLs). This work aims to evaluate and compare theperformance of bivariate methods for detecting QTLs in correlated phenotypes by linkageand association analyses. We applied these methods to data on Bone Mineral Density(BMD) variation, measured at the two skeletal sites, in a sample of males selected forextreme trait values. Our results demonstrate the relative gain, in particular for associationanalysis, of bivariate approaches when compared to univariate analyses. Finally, we studythe performances of association methods to detect QTLs in the GAW16 simulated familydata.
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https://tel.archives-ouvertes.fr/tel-00633981
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Aude Saint Pierre. Méthodes d'analyse génétique de traits quantitatifs corrélés : application à l'étude de la densité minérale osseuse. Génétique. Université Paris Sud - Paris XI, 2011. Français. ⟨NNT : 2011PA11T005⟩. ⟨tel-00633981v2⟩

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