Implantation of engineered human microvasculature to study human infectious diseases in mouse models - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue iScience Année : 2023

Implantation of engineered human microvasculature to study human infectious diseases in mouse models

Thomas Guilbert
  • Fonction : Auteur

Résumé

Animal models for studying human pathogens are crucially lacking. We describe the implantation in mice of engineered human mature microvasculature consisting of endothelial and perivascular cells embedded in collagen hydrogel that allows investigation of pathogen interactions with the endothelium, including in vivo functional studies. Using Neisseria meningitidis as a paradigm of human-restricted infection, we demonstrated the strength and opportunities associated with the use of this approach.
Fichier principal
Vignette du fichier
PIIS2589004223003632.pdf (4.7 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

inserm-04044803 , version 1 (24-03-2023)

Identifiants

Citer

Sophia Schönherr-Hellec, Eirini Chatzopoulou, Jean-Philippe Barnier, Yoann Atlas, Sébastien Dupichaud, et al.. Implantation of engineered human microvasculature to study human infectious diseases in mouse models. iScience, 2023, 26 (4), pp.106286. ⟨10.1016/j.isci.2023.106286⟩. ⟨inserm-04044803⟩
18 Consultations
14 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More