Identification of structural variation in mouse genomes - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Frontiers in Genetics Year : 2014

Identification of structural variation in mouse genomes


Structural variation is variation in structure of DNA regions affecting DNA sequence length and/or orientation. It generally includes deletions, insertions, copy-number gains, inversions, and transposable elements. Traditionally, the identification of structural variation in genomes has been challenging. However, with the recent advances in high-throughput DNA sequencing and paired-end mapping (PEM) methods, the ability to identify structural variation and their respective association to human diseases has improved considerably. In this review, we describe our current knowledge of structural variation in the mouse, one of the prime model systems for studying human diseases and mammalian biology. We further present the evolutionary implications of structural variation on transposable elements. We conclude with future directions on the study of structural variation in mouse genomes that will increase our understanding of molecular architecture and functional consequences of structural variation.
Fichier principal
Vignette du fichier
fgene-05-00192.pdf (2.74 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

inserm-03949464 , version 1 (20-01-2023)



Thomas Keane, Kim Wong, David Adams, Jonathan Flint, Alexandre Reymond, et al.. Identification of structural variation in mouse genomes. Frontiers in Genetics, 2014, 5, pp.192. ⟨10.3389/fgene.2014.00192⟩. ⟨inserm-03949464⟩
2 View
3 Download



Gmail Facebook Twitter LinkedIn More