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Article Dans Une Revue Nature Genetics Année : 2004

Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice

Résumé

Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a regulator of G protein signaling. We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait.
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inserm-03949431 , version 1 (20-01-2023)

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Binnaz Yalcin, Saffron a G Willis-Owen, Jan Fullerton, Anjela Meesaq, Robert M Deacon, et al.. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nature Genetics, 2004, 36, pp.1197 - 1202. ⟨10.1038/ng1450⟩. ⟨inserm-03949431⟩

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