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Article Dans Une Revue European Respiratory Journal Année : 2022

Respective role of non-pharmaceutical interventions on bronchiolitis outbreaks, an interrupted time series analysis based on a multinational surveillance system

Lea Lenglart (1) , Naim Ouldali (1, 2, 3, 4) , Kate Honeyford (5) , Zsolt Bognar (6) , Silvia Bressan (7) , Danilo Buonsenso (8) , Liviana da Dalt (7) , Tisham De (9) , Ruth Farrugia (10) , Ian Maconochie (11, 12) , Henriette Moll (13) , Rianne Oostenbrink (13) , Niccolo Parri (14) , Damian Roland (15, 16) , Katy Rose (11, 12) , Esra Akyüz Özkan (17) , François Angoulvant (18, 19) , Camille Aupiais (20, 3) , Clarissa Barber (21) , Michael Barrett (22, 23) , Romain Basmaci (24) , Susana Castanhinha (25) , Antonio Chiaretti (8) , Sheena Durnin (26) , Patrick Fitzpatrick (27) , Laszlo Fodor (28) , Borja Gomez (29) , Susanne Greber-Platzer (30) , Romain Guedj (31) , Florian Hey (32, 33) , Lina Jankauskaite (34) , Daniela Kohlfuerst (35) , Ines Mascarenhas (36) , Anna Maria Musolino (37) , Zanda Pučuka (38) , Sofia Reis (39) , Alexis Rybak (19, 3, 4) , Petra Salamon (6) , Matthias Schaffert (40) , Keren Shahar-Nissan (41) , Maria Chiara Supino (37) , Ozlem Teksam (42) , Caner Turan (43) , Roberto Velasco (44) , Ruud Nijman (9, 11, 12) , Luigi Titomanlio (19, 45) , Vanda Anacleto (36) , Orkun Aydin (42) , Elena Bellelli (37) , Ron Berant (41) , Thibault de Groc (24) , Sara Geitoeira (39) , Florian Hoffmann (32) , Franziska Leeb (30) , Fiona Leonard (22) , Mark Lyttle (21) , Lia Mano (26) , Vytenis Masillonis (34) , Rosa Morello (8) , Francisa Saraiva (36) , Gabor Simon (28) , Ines Silva Costa (39) , Joao Sous Marques (39) , Jonas Thüminger (40) , Corinne Vasilico (40) , Anna Chiara Vittucci (37) , Christoph Zurl (35)
1 Hôpital Robert Debré
2 CHU Sainte Justine [Montréal]
3 ECEVE (U1123 / UMR_S_1123) - Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables
4 ACTIV - Association Clinique et Thérapeutique Infantile du Val de Marne
5 The institute of cancer research [London]
6 Pál Heim Children's Hospital = Heim Pál Gyermekkórház [Budapest]
7 AOUP - Azienda Ospedale Università di Padova = Hospital-University of Padua
8 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
9 Imperial College London
10 Mater Dei Hospital [Malta]
11 St Mary's Hospital [London]
12 Hammersmith Hospital NHS Imperial College Healthcare
13 Erasmus MC - Erasmus University Medical Center [Rotterdam]
14 Azienda Ospedaliero Universitaria A. Meyer [Firenze, Italy]
15 University of Leicester
16 University Hospitals Leicester
17 OMU - Ondokuz Mayis University
18 UPCité - Université Paris Cité
19 AP-HP Hôpital universitaire Robert-Debré [Paris]
20 Hôpital Jean Verdier [AP-HP]
21 North Bristol NHS Trust [Bristol, UK]
22 CHI - Children's Health Ireland [Crumlin, Dublin, Ireland]
23 UCD - University College Dublin [Dublin]
24 Hôpital Louis Mourier - AP-HP [Colombes]
25 Centro Hospitalar de Lisboa Central E.P.E
26 COECU - CHI at Tallaght Children's Outpatient and Emergency Care Unit [Tallaght, Ireland]
27 TS - CHI at Temple Street [Temple Street, Ireland]
28 FCSGUTH - Fejér County Szent György University Teaching Hospital [Szekesfehervar, Hungary]
29 Hospital Universitario Cruces = Cruces University Hospital
30 Medizinische Universität Wien = Medical University of Vienna
31 EPOPé [CRESS - U1153 / UMR_A 1125] - Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique
32 Dr von Hauner Children's Hospital [Munich, Germany]
33 LMU - Ludwig-Maximilians University [Munich]
34 Hospital of Lithuanian University of Health Sciences Kauno Klinikos [Kaunas, Lithuania]
35 Medical University of Graz
36 Hospital Prof Doutor Fernando Fonseca [Amadora, Portugal]
37 IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital
38 CCUH - Children's Clinical University Hospital [Riga, Latvia]
39 CHTV - Centro Hospitalar Tondela-Viseu [Viseu, Portugal]
40 PMU - Paracelsus Medizinische Privatuniversität = Paracelsus Medical University
41 SCMC - Schneider Children’s Medical Center [Petah Tikva, Israel]
42 Hacettepe University = Hacettepe Üniversitesi
43 Mersin University
44 RHUH - Rio Hortega University Hospital (Hospital Universitario Río Hortega) [Valladolid, Spain]
45 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
Lea Lenglart
Romain Basmaci
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  • PersonId : 1047428
  • IdRef : 137467362
Caner Turan
  • Fonction : Auteur

Résumé

Background Bronchiolitis is a major source of morbimortality among young children worldwide. Non-pharmaceutical interventions (NPIs) implemented to reduce the spread of SARS-CoV-2 may have had an important impact on bronchiolitis outbreaks, as well as major societal consequences. Discriminating between their respective impacts would help define optimal public health strategies against bronchiolitis. We aimed to assess the respective impact of each NPI on bronchiolitis outbreaks in 14 European countries. Methods We conducted a quasi-experimental interrupted time-series analysis based on a multicentre international study. All children diagnosed with bronchiolitis presenting to the paediatric emergency department of one of the 27 centres from January 2018 to March 2021 were included. We assessed the association between each NPI and change in the bronchiolitis trend over time by seasonally adjusted multivariable quasi-Poisson regression modelling. Results In total, 42 916 children were included. We observed an overall cumulative 78% reduction (95%CI [−100;−54], p<0.0001) in bronchiolitis cases following NPI implementation. The decrease varied between countries from −97% (95%CI [−100;−47], p=0.0005) to −36% (95%CI [−79;+07], p=0.105). Full lockdown (IRR 0.21, 95%CI [0.14;0.30], p<0.001), secondary-school closure (IRR 0.33, 95%CI [0.20;0.52], p<0.0001), wearing a mask indoors (IRR 0.49, 95%CI [0.25;0.94], p=0.034), and teleworking (IRR 0.55, 95%CI [0.31;0.97], p=0.038) were independently associated with reducing bronchiolitis. Conclusion Several NPIs were associated with a reduction of bronchiolitis outbreaks, including full lockdown, school closure, teleworking and facial masking. Some of these public health interventions may be considered to further reduce the global burden of bronchiolitis.
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Dates et versions

inserm-03941039 , version 1 (16-01-2023)

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Lea Lenglart, Naim Ouldali, Kate Honeyford, Zsolt Bognar, Silvia Bressan, et al.. Respective role of non-pharmaceutical interventions on bronchiolitis outbreaks, an interrupted time series analysis based on a multinational surveillance system. European Respiratory Journal, 2022, pp.2201172. ⟨10.1183/13993003.01172-2022⟩. ⟨inserm-03941039⟩
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