Sacubitril/valsartan for the management of heart failure: A perspective viewpoint on current evidence - Archive ouverte HAL Access content directly
Journal Articles International Journal of Cardiology Year : 2020

Sacubitril/valsartan for the management of heart failure: A perspective viewpoint on current evidence

(1, 2) , (3) , (4, 5) , (6) , (7, 8) , (1) , (9, 10) , (6) , (1) , (11, 9, 10) , (12) , (13)
1
2
3
4
5
6
7
8
9
10
11
12
13

Abstract

Current international guidelines recommend switching angiotensin converting enzyme inhibitors (ACE-i) or angiotensin receptor blockers (ARBs) to sacubitril/valsartan (S/V) in stable outpatients affected by heart failure with reduced ejection fraction (HFrEF) who remain symptomatic despite being on optimal medical therapy. Since these guidelines were published, new data may support further clinical applications and benefits of S/V beyond ambulatory HFrEF patients. The efficacy of S/V seems to be consistent across a wider array of subgroups including age, sex, etiology of HF, comorbidities, EF and estimated cardiovascular risk, with safety and tolerability profiles similar to ACE-I and ARBs. Additional clinical trial data are required to confirm the potential benefits of S/V in patients with mid-range or preserved EF, as suggested by analysis of PARAGON-HF, or in combination with sodiumglucose co-transporter 2 inhibitors or in post-myocardial infarction HF. In this article we summarize the new evidence on the effects and safety profile of S/V in HF and discuss current perspectives and persisting gaps. Currently, available evidence may support S/V as a first-line therapy in outpatient or in-hospital HFrEF patients, and possibly also in HFmrEF patients.
Embargoed file
Embargoed file
Ne sera jamais visible

Dates and versions

inserm-03935024 , version 1 (11-01-2023)

Identifiers

Cite

Massimo Volpe, Johann Bauersachs, Antoni Bayés-Genís, Javed Butler, Alain Cohen-Solal, et al.. Sacubitril/valsartan for the management of heart failure: A perspective viewpoint on current evidence. International Journal of Cardiology, 2020, 327, pp.138 - 145. ⟨10.1016/j.ijcard.2020.11.071⟩. ⟨inserm-03935024⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More