The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue European Heart Journal Année : 2011

The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study

Ewa A Jankowska (1) , Bridget-Anne Kirwan (2, 3) , Mikhail Kosiborod (4, 5) , Javed Butler (6) , Stefan D Anker (7) , Theresa Mcdonagh (8) , Maria Dorobantu (9) , Jarosław Drozdz (10) , Gerasimos Filippatos (11, 12) , Andre Keren (13) , Irakli Khintibidze (14) , Hans Kragten (15) , Felipe A Martinez (16) , Marco Metra (17, 18) , Davor Milicic (19) , Marcus Ohlsson (20) , Alexander Parkhomenko (21) , Domingo A Pascual-Figal (22) , Frank Ruschitzka (23) , David Sim (24) , Hadi Skouri (25) , Peter van der Meer (26) , Basil S Lewis (27, 28) , Josep Comin-Colet (29, 30) , Stephan von Haehling (31, 32) , Alain Cohen-Solal (33) , Nicolas Danchin (34, 35) , Wolfram Doehner (36, 7, 32) , Henry J Dargie (37) , Michael Motro (38, 39) , Tim Friede (31, 32) , Vincent Fabien (40) , Fabio Dorigotti (40) , Stuart Pocock (3, 41) , Piotr Ponikowski (1)
1 Wrocław Medical University
2 SR - Socar Research S.A. [Nyon, Switzerland]
3 LSHTM - London School of Hygiene and Tropical Medicine
4 Saint Luke's Mid America Heart Institute
5 UMKC - University of Missouri [Kansas City]
6 UMMC - University of Mississippi Medical Center
7 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
8 King‘s College London
9 UB - Universitatea din Bucuresti
10 MUL - Medical University of Łódź
11 NKUA - National and Kapodistrian University of Athens
12 UOA - Université d'Athènes
13 AHRH - Assuta Hospital in Ramat HaHayal [Tel Aviv-Yafo, Israel]
14 Tbilisi State University
15 MUMC - Maastricht University Medical Centre
16 VSE - Prague University of Economics and Business
17 UniBs - Università degli Studi di Brescia = University of Brescia
18 Civic Hospital of Brescia
19 University of Zagreb
20 Skane University Hospital [Malmo]
21 NSC/MDSIC - National Scientific Center "M.D. Strazhesko Institute of Cardiology" [Kyiv, Ukraine]
22 Universidad de Murcia
23 University hospital of Zurich [Zurich]
24 NHCS - National Heart Centre Singapore
25 AUB - American University of Beirut Faculty of Medicine and Medical Center
26 UMCG - University Medical Center Groningen [Groningen]
27 Rappaport faculty of Medicine
28 Technion - Israel Institute of Technology [Haifa]
29 L’Hospitalet de Llobregat [Barcelona, Spain]
30 IDIBELL - Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
31 UMG - University Medical Center Göttingen
32 DZHK - German Center for Cardiovascular Research
33 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
34 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
35 HEGP - Hôpital Européen Georges Pompidou [APHP]
36 BIH - Berlin Institute of Health
37 University of Glasgow
38 TAU - Tel Aviv University
39 Kfar Saba and Sackler School of Medicine
40 Vifor Pharma Ltd [Glattbrugg, Switzerland]
41 UCL - University College of London [London]
Ewa A Jankowska
Wrocław Medical University
Bridget-Anne Kirwan
  • Fonction : Auteur
Socar Research S.A. [Nyon, Switzerland]
London School of Hygiene and Tropical Medicine
Mikhail Kosiborod
Saint Luke's Mid America Heart Institute
University of Missouri [Kansas City]
Javed Butler
  • Fonction : Auteur
University of Mississippi Medical Center
Stefan D Anker
  • Fonction : Auteur
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Theresa Mcdonagh
  • Fonction : Auteur
King‘s College London
Maria Dorobantu
Universitatea din Bucuresti
Jarosław Drozdz
Medical University of Łódź
Gerasimos Filippatos
National and Kapodistrian University of Athens
Université d'Athènes
Andre Keren
Assuta Hospital in Ramat HaHayal [Tel Aviv-Yafo, Israel]
Irakli Khintibidze
  • Fonction : Auteur
Tbilisi State University
Hans Kragten
  • Fonction : Auteur
Maastricht University Medical Centre
Felipe A Martinez
  • Fonction : Auteur
Prague University of Economics and Business
Marco Metra
  • Fonction : Auteur
Università degli Studi di Brescia = University of Brescia
Civic Hospital of Brescia
Davor Milicic
  • Fonction : Auteur
University of Zagreb
Marcus Ohlsson
Skane University Hospital [Malmo]
Alexander Parkhomenko
  • Fonction : Auteur
National Scientific Center "M.D. Strazhesko Institute of Cardiology" [Kyiv, Ukraine]
Domingo A Pascual-Figal
Universidad de Murcia
Frank Ruschitzka
University hospital of Zurich [Zurich]
David Sim
  • Fonction : Auteur
National Heart Centre Singapore
Hadi Skouri
American University of Beirut Faculty of Medicine and Medical Center
Peter van der Meer
  • Fonction : Auteur
University Medical Center Groningen [Groningen]
Basil S Lewis
Rappaport faculty of Medicine
Technion - Israel Institute of Technology [Haifa]
Josep Comin-Colet
L’Hospitalet de Llobregat [Barcelona, Spain]
Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
Stephan von Haehling
  • Fonction : Auteur
University Medical Center Göttingen
German Center for Cardiovascular Research
Alain Cohen-Solal
  • Fonction : Auteur
Marqueurs cardiovasculaires en situation de stress
Nicolas Danchin
Assistance publique - Hôpitaux de Paris (AP-HP)
Hôpital Européen Georges Pompidou [APHP]
Wolfram Doehner
Berlin Institute of Health
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
German Center for Cardiovascular Research
Henry J Dargie
  • Fonction : Auteur
University of Glasgow
Michael Motro
  • Fonction : Auteur
Tel Aviv University
Kfar Saba and Sackler School of Medicine
Tim Friede
University Medical Center Göttingen
German Center for Cardiovascular Research
Vincent Fabien
Vifor Pharma Ltd [Glattbrugg, Switzerland]
Fabio Dorigotti
Vifor Pharma Ltd [Glattbrugg, Switzerland]
Stuart Pocock
London School of Hygiene and Tropical Medicine
University College of London [London]
Piotr Ponikowski
Wrocław Medical University

Résumé

Aims: Patients with heart failure (HF) and iron deficiency experience poor health-related quality of life (HRQoL). We evaluated the impact of intravenous (IV) ferric carboxymaltose (FCM) vs. placebo on HRQoL for the AFFIRM-AHF population. Methods and results: The baseline 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12), which was completed for 1058 (535 and 523) patients in the FCM and placebo groups, respectively, was administered prior to randomization and at Weeks 2, 4, 6, 12, 24, 36, and 52. The baseline KCCQ-12 overall summary score (OSS) mean ± standard error was 38.7 ± 0.9 (FCM group) and 37.1 ± 0.8 (placebo group); corresponding values for the clinical summary score (CSS) were 40.9 ± 0.9 and 40.1 ± 0.9. At Week 2, changes in OSS and CSS were similar for FCM and placebo. From Week 4 to Week 24, patients assigned to FCM had significantly greater improvements in OSS and CSS scores vs. placebo [adjusted mean difference (95% confidence interval, CI) at Week 4: 2.9 (0.5-5.3, P = 0.018) for OSS and 2.8 (0.3-5.3, P = 0.029) for CSS; adjusted mean difference (95% CI) at Week 24: 3.0 (0.3-5.6, P = 0.028) for OSS and 2.9 (0.2-5.6, P = 0.035) for CSS]. At Week 52, the treatment effect had attenuated but remained in favour of FCM. Conclusion: In iron-deficient patients with HF and left ventricular ejection fraction ≤50% who had stabilized after an episode of acute HF, treatment with IV FCM, compared with placebo, results in clinically meaningful beneficial effects on HRQoL as early as 4 weeks after treatment initiation, lasting up to Week 24.

Domaines

Cardiologie et système cardiovasculaire
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https://inserm.hal.science/inserm-03934856

Soumis le : mercredi 11 janvier 2023-14:57:27

Dernière modification le : vendredi 5 avril 2024-14:38:02

Archivage à long terme le : mercredi 12 avril 2023-23:34:24

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inserm-03934856 , version 1 (11-01-2023)

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Ewa A Jankowska, Bridget-Anne Kirwan, Mikhail Kosiborod, Javed Butler, Stefan D Anker, et al.. The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study. European Heart Journal, 2011, 42 (31), pp.3021 - 3022. ⟨10.1093/eurheartj/ehab365⟩. ⟨inserm-03934856⟩

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