BIOFIRE® Blood Culture IDentification 2 (BCID2) panel for early adaptation of antimicrobial therapy in adult patients with bloodstream infections: a real-life experience - Archive ouverte HAL Access content directly
Journal Articles Diagnostic Microbiology and Infectious Disease Year : 2023

BIOFIRE® Blood Culture IDentification 2 (BCID2) panel for early adaptation of antimicrobial therapy in adult patients with bloodstream infections: a real-life experience

(1) , (2, 3) , (3) , (4) , (4) , (4) , (3) , (2, 4) , (2, 4)
1
2
3
4

Abstract

Our objective was to assess the effectiveness of a multiplex PCR panel for blood culture identification (BCID2) on the implementation of appropriate antimicrobial therapy. We conducted a monocentric pre/post study comparing the time to result from direct microscopic examination (DE) to bacterial identification (BI) in positive blood cultures between 2 different periods: P1 without BCID2 and P2 with BCID2. Appropriate treatments prescribed before DE and after DE / BCID2 and after BI / BCID2 were compared using direct proportion comparison and survival analysis. For mono-microbial bloodstream infections, the proportion of appropriate antimicrobial treatment after DE was 50% in P1 vs. 87.5% after BCID2 in P2 (P < 0.001) for Gram-negative bacteria and 33.0% in P1 vs. 64.4% in P2 (P < 0.01) for Gram-positive bacteria. A significant difference (P = 0.04) was recorded with survival curves for Gram positive bacteria. BCID2 seems effective in reducing the time for prescribing appropriate antimicrobials.
Not file

Dates and versions

inserm-03874474 , version 1 (28-11-2022)

Identifiers

Cite

Anne Donnars, Rafael Mahieu, Charles Declerck, Rachel Chenouard, Carole Lemarié, et al.. BIOFIRE® Blood Culture IDentification 2 (BCID2) panel for early adaptation of antimicrobial therapy in adult patients with bloodstream infections: a real-life experience. Diagnostic Microbiology and Infectious Disease, 2023, 105 (2), pp.115858. ⟨10.1016/j.diagmicrobio.2022.115858⟩. ⟨inserm-03874474⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More