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Journal Articles Trends in Genetics Year : 2022

Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions

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Abstract

Although the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level? This is because current understanding limits the influence of telomeres to adjacent subtelomeric regions despite the wide-ranging impact of telomeres. Emerging work in two distinct aspects offers opportunities to bridge this gap. First, telomere-binding factors were found with non-telomeric functions. Second, locally induced DNA secondary structures called G-quadruplexes are notably abundant in telomeres, and gene regulatory regions genome wide. Many telomeric factors bind to G-quadruplexes for non-telomeric functions. Here we discuss a more general model of how telomeres impact the non-telomeric genome – through factors that associate at telomeres and genome wide – and influence cell-intrinsic functions, particularly aging, cancer, and pluripotency.
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inserm-03858948 , version 1 (18-11-2022)

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Soujanya Vinayagamurthy, Sulochana Bagri, Jean-Louis Mergny, Shantanu Chowdhury. Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions. Trends in Genetics, 2022, ⟨10.1016/j.tig.2022.10.002⟩. ⟨inserm-03858948⟩
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