Association of high SARS-CoV-2 RNAemia with diabetes and mortality in critically ill COVID-19 patients - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue iScience Année : 2022

Association of high SARS-CoV-2 RNAemia with diabetes and mortality in critically ill COVID-19 patients

Résumé

It has been suggested that during the period of respiratory worsening of severe COVID-19 patients, viral replication plays a less important role than inflammation. Using the droplet-based digital PCR (ddPCR) for precise quantification of plasma SARS-CoV-2 viral load (SARS-CoV-2 RNAemia), we investigated the relationship between plasma viral load, comorbidities, and mortality of 122 critically ill COVID-19 patients. SARS-CoV-2 RNAemia was detected by ddPCR in 90 (74%) patients, ranging from 70 to 213,152 copies per mL. A high (>1 000 copies/ml) or very high (>10,000 copies/ml) SARS-Cov-2 RNAemia was observed in 46 patients (38%), of which 26 were diabetic. Diabetes was independently associated with a higher SARS-CoV-2 RNAemia. In multivariable logistic regression models, SARS-CoV-2 RNAemia was strongly and independently associated with day-60 mortality. Early initiation of antiviral therapies might be considered in COVID-19 critically ill patients with high RNAemia.

Mots clés

Fichier principal
Vignette du fichier
iScience2589004222003455.pdf (1.17 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

inserm-03857895 , version 1 (17-11-2022)

Identifiants

Citer

Mehran Monchi, Thomas Bruneau, Sebastien Jochmans, David Veyer, Aurelia Pitsch, et al.. Association of high SARS-CoV-2 RNAemia with diabetes and mortality in critically ill COVID-19 patients. iScience, 2022, 25 (5), pp.104075. ⟨10.1016/j.isci.2022.104075⟩. ⟨inserm-03857895⟩
7 Consultations
15 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More