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Article Dans Une Revue Practical Laboratory Medicine Année : 2022

Point of care creatinine derived eGFR measurement in capillary blood for identifying patients at risk

Résumé

INTRODUCTION: The aim of the study was to assess the clinical reliability of eGFR values estimated with a creatinine measurement from a point of care (StatSensor®) compared with measured GFR (mGFR) by a gold standard method. METHODS: We prospectively included 113 patients undergoing renal function assessment. We compared eGFR using creatinine from capillary blood or venous blood measured by StatSensor® and measured GFR (mGFR) by Passing Bablok regression. Performance of eGFR was estimated by biais, precision and accuracy. RESULTS: A total of 113 subjects were included. Median eGFR values were 59 (10-132), 52 (10-123) and 51 (10-131) ml/min/1.73 m(2) for enzymatic, capillary and venous measurements, respectively. There was no difference between P30 and P10 for the three eGFR values (p = 0.11 and p = 0.1 respectively). StatSensor® eGFR tended to be underestimated compared to mGFR. For CKD stage 4/5 patients, concordance was 79 and 84% for eGFR with capillary creatinine and venous creatinine respectively. For mGFR\textless 60 ml/min/1.73 m(2), concordance was 84 and 88% with capillary creatinine and venous creatinine respectively. CONCLUSION: The use of a handheld blood creatinine monitoring system with eGFR calculation provides a good estimation of GFR and allow to identify patients at high risk of acute kidney injury.
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Dates et versions

inserm-03833162 , version 1 (28-10-2022)

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S. Lemoine, A. C. Rouveure, L. Dubourg, S. Pelletier, C. Marolho, et al.. Point of care creatinine derived eGFR measurement in capillary blood for identifying patients at risk. Practical Laboratory Medicine, 2022, 31, pp.e00296. ⟨10.1016/j.plabm.2022.e00296⟩. ⟨inserm-03833162⟩
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