Risk for Incident Heart Failure: A Subject‐Level Meta‐Analysis From the Heart “OMics” in AGEing (HOMAGE) Study - Archive ouverte HAL Access content directly
Journal Articles Journal of the American Heart Association Year : 2017

Risk for Incident Heart Failure: A Subject‐Level Meta‐Analysis From the Heart “OMics” in AGEing (HOMAGE) Study

(1) , (1) , (2, 3, 4, 5) , (1) , (1) , (1) , (6) , (6) , (7) , (8) , (9) , (9) , (10) , (8, 11) , (1) , (1) , (3, 2, 12)
1
2
3
4
5
6
7
8
9
10
11
12

Abstract

Background To address the need for personalized prevention, we conducted a subject‐level meta‐analysis within the framework of the Heart “OMics” in AGEing (HOMAGE) study to develop a risk prediction model for heart failure (HF) based on routinely available clinical measurements. Methods and Results Three studies with elderly persons (Health Aging and Body Composition [Health ABC], Valutazione della PREvalenza di DIsfunzione Cardiaca asinTOmatica e di scompenso cardiaco [PREDICTOR], and Prospective Study of Pravastatin in the Elderly at Risk [PROSPER]) were included to develop the HF risk function, while a fourth study (Anglo‐Scandinavian Cardiac Outcomes Trial [ASCOT]) was used as a validation cohort. Time‐to‐event analysis was conducted using the Cox proportional hazard model. Incident HF was defined as HF hospitalization. The Cox regression model was evaluated for its discriminatory performance (area under the receiver operating characteristic curve) and calibration (Grønnesby‐Borgan χ 2 statistic). During a follow‐up of 3.5 years, 470 of 10 236 elderly persons (mean age, 74.5 years; 51.3% women) developed HF . Higher age, BMI, systolic blood pressure, heart rate, serum creatinine, smoking, diabetes mellitus, history of coronary artery disease, and use of antihypertensive medication were associated with increased HF risk. The area under the receiver operating characteristic curve of the model was 0.71, with a good calibration (χ 2 7.9, P =0.54). A web‐based calculator was developed to allow easy calculations of the HF risk. Conclusions Simple measurements allow reliable estimation of the short‐term HF risk in populations and patients. The risk model may aid in risk stratification and future HF prevention strategies.
Fichier principal
Vignette du fichier
JAHA.116.005231.pdf (407.86 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

inserm-03833086 , version 1 (28-10-2022)

Identifiers

Cite

Lotte Jacobs, Ljupcho Efremov, João Pedro Ferreira, Lutgarde Thijs, Wen‐Yi Yang, et al.. Risk for Incident Heart Failure: A Subject‐Level Meta‐Analysis From the Heart “OMics” in AGEing (HOMAGE) Study. Journal of the American Heart Association, 2017, 6 (5), pp.e005231. ⟨10.1161/JAHA.116.005231⟩. ⟨inserm-03833086⟩
44 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More