Cardiovascular and metabolic responses to passive hypoxic conditioning in overweight and mildly obese individuals - Archive ouverte HAL Access content directly
Journal Articles AJP - Regulatory, Integrative and Comparative Physiology Year : 2020

Cardiovascular and metabolic responses to passive hypoxic conditioning in overweight and mildly obese individuals

(1, 2) , (1, 2) , (1, 2) , (1, 2) , (1, 2) , (1, 2) , (1, 2) , (1, 2) , (1, 2)
1
2

Abstract

Although severe intermittent hypoxia (IH) is well known to induce deleterious cardiometabolic consequences, moderate IH may induce positive effects in obese individuals. The present study aimed to evaluate the effect of two hypoxic conditioning programs on cardiovascular and metabolic health status of overweight or obese individuals. In this randomized single-blind controlled study, 35 subjects (54 ± 9.3 yr, 31.7 ± 3.5 kg/m 2 ) were randomized into three 8-wk interventions (three 1-h sessions per week): sustained hypoxia (SH), arterial oxygen saturation ([Formula: see text]) = 75%; IH, 5 min [Formula: see text] = 75% – 3 min normoxia; normoxia. Ventilation, heart rate, blood pressure, and tissue oxygenation were measured during the first and last hypoxic conditioning sessions. Vascular function, blood glucose and insulin, lipid profile, nitric oxide metabolites, and oxidative stress were evaluated before and after the interventions. Both SH and IH increased ventilation in hypoxia (+1.8 ± 2.1 and +2.3 ± 3.6 L/min, respectively; P < 0.05) and reduced normoxic diastolic blood pressure (−12 ± 15 and −13 ± 10 mmHg, respectively; P < 0.05), whereas changes in normoxic systolic blood pressure were not significant (+3 ± 9 and −6 ± 13 mmHg, respectively; P > 0.05). IH only reduced heart rate variability (e.g., root-mean-square difference of successive normal R-R intervals in normoxia −21 ± 35%; P < 0.05). Both SH and IH induced no significant change in body mass index, vascular function, blood glucose, insulin and lipid profile, nitric oxide metabolites, or oxidative stress, except for an increase in superoxide dismutase activity following SH. This study indicates that passive hypoxic conditioning in obese individuals induces some positive cardiovascular and respiratory improvements despite no change in anthropometric data and even a reduction in heart rate variability during IH exposure.
Embargoed file
Embargoed file
Ne sera jamais visible

Dates and versions

inserm-03797862 , version 1 (04-10-2022)

Identifiers

Cite

Samarmar Chacaroun, Anna Borowik, Stephane Doutreleau, Elise Belaidi, Bernard Wuyam, et al.. Cardiovascular and metabolic responses to passive hypoxic conditioning in overweight and mildly obese individuals. AJP - Regulatory, Integrative and Comparative Physiology, 2020, 319 (2), pp.R211-R222. ⟨10.1152/ajpregu.00311.2019⟩. ⟨inserm-03797862⟩

Collections

INSERM UGA
1 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More