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Rapid SARS-CoV-2 inactivation by mercury and LED UV-C lamps on different surfaces

Abstract : SARS-CoV-2 remains infectious for several hours on surfaces. It can be inactivated by UV-C irradiation but optimal conditions for rapid inactivation, especially on non-plastic surfaces remains unclear. A SARS-CoV-2 inoculum was irradiated with a UV-C LED (265 nm) or a UV-C mercury lamp (254 nm). Infectivity titers (TCID50/mL) and inactivation rates were then quantified on plastic, steel, tissue, paper and cardboard surfaces. We demonstrated that efficient SARS-CoV-2 inactivation (> 99.999% on plastic and steel, ≥ 99.8% on tissue, paper and cardboard) can be achieved by both a UV-C mercury lamp and a UV-C LED after 30 s of irradiations at 3 cm, corresponding to UV-C doses of 92.85 and 44.7 mJ/cm2, respectively. Inactivation on a plastic surface was more efficient with the mercury UV-C lamp (p < 0.005). The mercury UV-C lamp could be more relevant than the LED in high-risk settings, such as medical care or research laboratories.
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Contributor : Julien Marlet Connect in order to contact the contributor
Submitted on : Friday, August 26, 2022 - 2:28:29 PM
Last modification on : Friday, September 9, 2022 - 11:14:57 AM


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Marianne Maquart, Julien Marlet. Rapid SARS-CoV-2 inactivation by mercury and LED UV-C lamps on different surfaces. Photochemical & Photobiological Sciences , Springer, 2022, Online ahead of print. ⟨10.1007/s43630-022-00292-2⟩. ⟨inserm-03761842⟩



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