Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Anouk La Rose; Anouk Groenen; Benedek Halmos; Venetia Bazioti; Martijn G.S. Rutten; Kishore Krishnamurthy; Mirjam Koster; Niels Kloosterhuis; Marieke Smit; Rick Havinga; Gilles Mithieux; Fabienne Rajas; Folkert Kuipers; Maaike Oosterveer; Marit Westerterp

doi:10.1016/j.ymgmr.2022.100872

Journal Articles Molecular Genetics and Metabolism Reports Year : 2022

Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

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Anouk La Rose

Function : Author

University of Groningen [Groningen]

Anouk Groenen

Function : Author

University of Groningen [Groningen]

Benedek Halmos

Function : Author

University of Groningen [Groningen]

Venetia Bazioti

Function : Author

University of Groningen [Groningen]

Martijn G.S. Rutten

Function : Author

University of Groningen [Groningen]

Kishore Krishnamurthy

Function : Author

University of Groningen [Groningen]

Mirjam Koster

Function : Author

University of Groningen [Groningen]

Niels Kloosterhuis

Function : Author

University of Groningen [Groningen]

Marieke Smit

Function : Author

University of Groningen [Groningen]

Rick Havinga

Function : Author

University of Groningen [Groningen]

Gilles Mithieux

Function : Author

Nutrition, diabète et cerveau

Fabienne Rajas

Function : Author

Nutrition, diabète et cerveau

Folkert Kuipers

Function : Author

University of Groningen [Groningen]

Maaike Oosterveer

Function : Author

University of Groningen [Groningen]

Marit Westerterp

Function : Author

University of Groningen [Groningen]

Abstract

Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

Keywords

Atherosclerosis G6P Glucose-6-phosphate G6PC1 Glucose-6-phosphatase enzyme GSD Ia Glycogen storage disease type 1a HDL High-density lipoprotein Hyperlipidemia Ldlr−/− LDL receptor deficient PUFA Poly-unsaturated FA SFA Saturated fatty acids TG Triglycerides VLDL Very-low-density lipoprotein WTD Western-type diet.

Domains

Neurons and Cognition [q-bio.NC]

Fichier principal

1-s2.0-S2214426922000325-main.pdf (1.76 Mo)

Origin : Publication funded by an institution

Marie-Ange Di Carlo : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-03740218

Submitted on : Friday, July 29, 2022-10:25:29 AM

Last modification on : Friday, September 30, 2022-11:50:06 AM

Long-term archiving on: Sunday, October 30, 2022-6:14:22 PM

Dates and versions

inserm-03740218 , version 1 (29-07-2022)

Identifiers

HAL Id : inserm-03740218 , version 1
DOI : 10.1016/j.ymgmr.2022.100872
PUBMED : 35782606
PUBMEDCENTRAL : PMC9248218

Cite

Anouk La Rose, Anouk Groenen, Benedek Halmos, Venetia Bazioti, Martijn G.S. Rutten, et al.. Increased atherosclerosis in a mouse model of glycogen storage disease type 1a. Molecular Genetics and Metabolism Reports, 2022, 31, pp.100872. ⟨10.1016/j.ymgmr.2022.100872⟩. ⟨inserm-03740218⟩

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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

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