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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Abstract : Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
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https://www.hal.inserm.fr/inserm-03740218
Contributor : Marie-Ange Di Carlo Connect in order to contact the contributor
Submitted on : Friday, July 29, 2022 - 10:25:29 AM
Last modification on : Friday, September 30, 2022 - 11:50:06 AM

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Anouk La Rose, Anouk Groenen, Benedek Halmos, Venetia Bazioti, Martijn G.S. Rutten, et al.. Increased atherosclerosis in a mouse model of glycogen storage disease type 1a. Molecular Genetics and Metabolism Reports, Elsevier, 2022, 31, pp.100872. ⟨10.1016/j.ymgmr.2022.100872⟩. ⟨inserm-03740218⟩

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