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Journal Articles Light: Science and Applications Year : 2020

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

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Abstract

Abstract Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue but lacks functional information. We present dynamic full-field optical coherence tomography as a technique to noninvasively image living human induced pluripotent stem cell-derived retinal organoids. Coloured images with an endogenous contrast linked to organelle motility are generated, with submicrometre spatial resolution and millisecond temporal resolution, creating a way to identify specific cell types in living tissue via their function.
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Dates and versions

inserm-03726485 , version 1 (18-07-2022)

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Jules Scholler, Kassandra Groux, Olivier Goureau, José-Alain Sahel, Mathias Fink, et al.. Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids. Light: Science and Applications, 2020, 9 (1), pp.140. ⟨10.1038/s41377-020-00375-8⟩. ⟨inserm-03726485⟩
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