Skip to Main content Skip to Navigation
Journal articles

Cross‐sectional case‐control study of the relationships between pharyngeal compliance and heart rate variability indices in childhood obstructive sleep apnoea

Abstract : A combination of noradrenergic and antimuscarinic agents reduces the apnea-hypopnea index (AHI) in adult patients with obstructive sleep apnoea (OSA) via reduced upper airway collapsibility, suggesting that a shift in the sympathovagal balance improves OSA. The objectives of our present case-control study were to assess heart rate variability (HRV) indices in the stages of sleep in children with and without OSA to evaluate OSA-induced sleep HRV modifications and to assess whether increased collapsibility measured during wakefulness is associated with reduced sympathetic activity during non-rapid eye movement (NREM) sleep. Three groups of 15 children were matched by sex, age, z-score of body mass index and ethnicity: non-OSA (obstructive AHI [OAHI] <2 events/hr), mild (OAHI ≥2 to <5 events/hr) or moderate-severe (OAHI ≥5 events/hr) OSA. Pharyngeal compliance was measured during wakefulness using acoustic pharyngometry. HRV indices (time and frequency domain variables) were calculated on 5-min electrocardiography recordings from polysomnography during wakefulness, NREM and REM sleep in periods free of any event. As compared to children without OSA, those with OSA (n = 30) were characterised by increased compliance and no physiological parasympathetic tone increase in REM sleep. Children with increased pharyngeal compliance (n = 21) had a higher OAHI due to higher AHI in NREM sleep, whereas their sympathetic tone was lower than that of those with normal compliance (n = 24). In conclusion, children with increased pharyngeal compliance exhibit decreased sympathetic tone associated with increased AHI in NREM sleep. Therapeutics directed at sympathovagal balance modifications should be tested in childhood OSA.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03701227
Contributor : Boris Matrot Connect in order to contact the contributor
Submitted on : Tuesday, June 21, 2022 - 6:24:48 PM
Last modification on : Saturday, June 25, 2022 - 3:44:06 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Plamen Bokov, François‐xavier Mauvais, Amélia Madani, Boris Matrot, Michel Lecendreux, et al.. Cross‐sectional case‐control study of the relationships between pharyngeal compliance and heart rate variability indices in childhood obstructive sleep apnoea. Journal of Sleep Research, Wiley, 2021, 30 (5), pp.e13337. ⟨10.1111/jsr.13337⟩. ⟨inserm-03701227⟩

Share

Metrics

Record views

0