Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Analysis of GWAS-nominated loci for lung cancer and COPD revealed a new asthma locus

Abstract : Background: Asthma, lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are three respiratory diseases characterized by complex mechanisms underlying and genetic predispositions, with asthma having the highest calculated heritability. Despite efforts deployed in the last decades, only a small part of its heritability has been elucidated. It was hypothesized that shared genetic factors by these three diseases could help identify new asthma loci. Methods: GWAS-nominated LC and COPD loci were selected among studies performed in Caucasian cohorts using the GWAS Catalog. Genetic analyses were carried out for these loci in the Saguenay-Lac-Saint-Jean (SLSJ) asthma familial cohort and then replicated in two independent cohorts (the Canadian Cohort Obstructive Lung Disease [Can-COLD] and the Epidemiological Study of the Genetics and Environment of Asthma [EGEA]). Results: Analyses in the SLSJ cohort identified 2851 and 4702 genetic variants to be replicated in the CanCOLD and EGEA cohorts for LC and COPD loci respectively. Replication and meta-analyses allowed the association of one new locus with asthma, 2p24.3, from COPD studies. None was associated from LC studies reported. Conclusions: The approach used in this study contributed to better understand the heritability of asthma with shared genetic backgrounds of respiratory diseases.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03693135
Contributor : Odile Malbec Connect in order to contact the contributor
Submitted on : Friday, June 10, 2022 - 11:32:25 AM
Last modification on : Saturday, June 25, 2022 - 3:44:18 AM

File

s12890-022-01890-7.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Anne-Marie Madore, yohan Bossé, Patricia Margaritte-Jeannin, Emily Vucic, Wan Lam, et al.. Analysis of GWAS-nominated loci for lung cancer and COPD revealed a new asthma locus. BMC Pulmonary Medicine, BioMed Central, 2022, 22 (1), pp.155. ⟨10.1186/s12890-022-01890-7⟩. ⟨inserm-03693135⟩

Share

Metrics

Record views

2434

Files downloads

19533