Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea - Archive ouverte HAL Access content directly
Journal Articles BMC Microbiology Year : 2022

Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea

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Abstract

Background: Diosmectite, a natural colloidal clay, has been used worldwide for a number of approved indications, including the treatment of chronic functional diarrhea. Here, we used high-resolution whole metagenome shotgun sequencing to assess the impact of a 5 weeks administration of diosmectite (3 g/sachet, 3 sachets/day) on the fecal microbiota of 35 adults with functional chronic diarrhea. Results: Gut microbiota was not impacted by diosmectite administration. In particular, richness remained stable and no microbial species displayed a significant evolution. Segregating patients either by diosmectite response (non responder, early responder, late responder) or by nationality (Great-Britain or Netherlands) yielded the same results. Conclusion: We concluded that no microbiota-related physiological alterations are expected upon long-term treatment with diosmectite.
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Dates and versions

inserm-03690762 , version 1 (08-06-2022)

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Kévin da Silva, Susie Guilly, Florence Thirion, Emmanuelle Le Chatelier, Nicolas Pons, et al.. Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea. BMC Microbiology, 2022, 22 (1), pp.54. ⟨10.1186/s12866-022-02464-7⟩. ⟨inserm-03690762⟩
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