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Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea

Abstract : Background: Diosmectite, a natural colloidal clay, has been used worldwide for a number of approved indications, including the treatment of chronic functional diarrhea. Here, we used high-resolution whole metagenome shotgun sequencing to assess the impact of a 5 weeks administration of diosmectite (3 g/sachet, 3 sachets/day) on the fecal microbiota of 35 adults with functional chronic diarrhea. Results: Gut microbiota was not impacted by diosmectite administration. In particular, richness remained stable and no microbial species displayed a significant evolution. Segregating patients either by diosmectite response (non responder, early responder, late responder) or by nationality (Great-Britain or Netherlands) yielded the same results. Conclusion: We concluded that no microbiota-related physiological alterations are expected upon long-term treatment with diosmectite.
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Submitted on : Wednesday, June 8, 2022 - 3:32:19 PM
Last modification on : Friday, August 5, 2022 - 2:38:11 PM
Long-term archiving on: : Friday, September 9, 2022 - 7:24:41 PM


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Kévin da Silva, Susie Guilly, Florence Thirion, Emmanuelle Le Chatelier, Nicolas Pons, et al.. Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea. BMC Microbiology, BioMed Central, 2022, 22 (1), pp.54. ⟨10.1186/s12866-022-02464-7⟩. ⟨inserm-03690762⟩



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