Skip to Main content Skip to Navigation
Journal articles

BRAIN ANOMALIES IN EARLY PSYCHOSIS: FROM SECONDARY TO PRIMARY PSYCHOSIS

Abstract : Brain anomalies are frequently found in early psychoses. Although they may remain undetected for many years, their interpretation is critical for differential diagnosis. In secondary psychoses, their identification may allow specific management. They may also shed light on various pathophysiological aspects of primary psychoses. Here we reviewed cases of secondary psychoses associated with brain anomalies, reported over a 20-year period in adolescents and young adults aged 13 to 30 years old. We considered age at first psychotic symptoms, relevant medical history, the nature of psychiatric symptoms, clinical red flags, the nature of the brain anomaly reported, and the underlying disease. We discuss the relevance of each brain area in light of normal brain function, recent case-control studies, and postulated pathophysiology. We show that anomalies in all regions, whether diffuse, multifocal, or highly localized, may lead to psychosis, without necessarily being associated with non-psychiatric symptoms. This underlines the interest of neuroimaging in the initial workup, and supports the hypothesis of psychosis as a global network dysfunction that involves many different regions.
Complete list of metadata

https://www.hal.inserm.fr/inserm-03684095
Contributor : Clara Martinez Rico Connect in order to contact the contributor
Submitted on : Wednesday, June 1, 2022 - 10:41:11 AM
Last modification on : Saturday, June 25, 2022 - 3:26:23 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2022-12-01

Please log in to resquest access to the document

Identifiers

Citation

Anton Iftimovici, Boris Chaumette, Edouard Duchesnay, Marie-Odile Krebs. BRAIN ANOMALIES IN EARLY PSYCHOSIS: FROM SECONDARY TO PRIMARY PSYCHOSIS. Neuroscience & Biobehavioral Reviews, Oxford: Elsevier Ltd., 2022, pp.104716. ⟨10.1016/j.neubiorev.2022.104716⟩. ⟨inserm-03684095⟩

Share

Metrics

Record views

9