The role of neurotrophin genes involved in the vulnerability to gambling disorder - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2022

The role of neurotrophin genes involved in the vulnerability to gambling disorder

Résumé

Evidence about the involvement of genetic factors in the development of gambling disorder (GD) has been assessed. Among studies assessing heritability and biological vulnerability for GD, neurotrophin (NTF) genes have emerged as promising targets, since a growing literature showed a possible link between NTF and addiction-related disorders. Thus, we aimed to explore the role of NTF genes and GD with the hypothesis that some NTF gene polymorphisms could constitute biological risk factors. The sample included 166 patients with GD and 191 healthy controls. 36 single nucleotide polymorphisms (SNPs) from NTFs (NGF, NGFR, NTRK1, BDNF, NTRK2, NTF3, NTRK3, NTF4, CNTF and CNTFR) were selected and genotyped. Linkage disequilibrium (LD) and haplotype constructions were analyzed, in relationship with the presence of GD. Finally, regulatory elements overlapping the identified SNPs variants associated with GD were searched. The between groups comparisons of allele frequencies indicated that 6 SNPs were potentially associated with GD. Single and multiplemarker analyses showed a strong association between both NTF3 and NTRK2 genes, and GD. The present study supports the involvement of the NTF family in the aetiopathogenesis of GD. An altered cross-regulation of different NTF members signalling pathways might be considered as a biological vulnerability factor for GD.
Fichier principal
Vignette du fichier
Solé-Morata et al. Sci Rep. 2022.pdf (1.32 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

inserm-03658543 , version 1 (04-05-2022)

Identifiants

Citer

Neus Solé-Morata, Isabel Baenas, Mikel Etxandi, Roser Granero, Sonia Forcales, et al.. The role of neurotrophin genes involved in the vulnerability to gambling disorder. Scientific Reports, 2022, 12 (1), pp.6925. ⟨10.1038/s41598-022-10391-w⟩. ⟨inserm-03658543⟩

Collections

INSERM UP-SANTE
12 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More