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Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1

Abstract : Beclin 1 has a key role in the initiation of autophagy, a process of self-cannibalism in which cytoplasmic constituents are sequestered and targeted for lysosomal degradation. In a recent issue of Cell Death & Disease, Wirawan et al. report the significant finding that caspases can cleave Beclin 1, thereby destroying its pro-autophagic activity. Moreover, the C-terminal fragment of Beclin 1 that results from this cleavage acquires a new function and can amplify mitochondrion-mediated apoptosis. Of note, the BH3 domain of Beclin 1 remains within the N-terminal fragment, which has no detectable pro-apoptotic activity. These findings provide important insights into the molecular cross talk between autophagy and apoptosis.
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https://www.hal.inserm.fr/inserm-03653069
Contributor : Mojgan Djavaheri-Mergny Connect in order to contact the contributor
Submitted on : Wednesday, April 27, 2022 - 12:42:42 PM
Last modification on : Friday, July 29, 2022 - 11:18:59 AM

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M Djavaheri-Mergny, M Maiuri, G Kroemer. Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene, Nature Publishing Group, 2010, 29 (12), pp.1717-1719. ⟨10.1038/onc.2009.519⟩. ⟨inserm-03653069⟩

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