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Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

Abstract : G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.
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https://www.hal.inserm.fr/inserm-03653049
Contributor : Mojgan Djavaheri-Mergny Connect in order to contact the contributor
Submitted on : Wednesday, April 27, 2022 - 12:26:00 PM
Last modification on : Thursday, September 29, 2022 - 5:02:54 AM
Long-term archiving on: : Friday, July 29, 2022 - 9:17:29 AM

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Jennifer Beauvarlet, Jean‐louis Mergny, Mojgan Djavaheri-Mergny. Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis. Molecular & Cellular Oncology, Taylor et Francis, 2019, 6 (4), pp.1604047. ⟨10.1080/23723556.2019.1604047⟩. ⟨inserm-03653049⟩

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