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Les gabapentinoïdes : une revue de la littérature

Abstract : The objective of this review is to produce a synthesis of the state of knowledge regarding the epidemiology, pharmacology, clinical and analytical toxicology of gabapentinoids. The pharmacological class of gabapentinoids is mainly represented by gabapentin and pregabalin, which were marketed around the 2000s. Soon after their marketing, cases of misuse were documented and related to abuse and dependence. Gabapentinoids are well-tolerated and acute poisonings are most often benign, except in cases of poly-intoxication, particularly with opiates. Pregabalin increases the risk of death due to opioid overdose. To date, there is no specific treatment, management is based on symptomatic treatment. Numerous analytical methods allowing the detection and determination of pregabalin and gabapentin in blood, urine and hair have been published, the analyzes are mainly carried out in liquid chromatography coupled to tandem mass spectrometry. Testing for gabapentinoids should be done routinely in death related to substance abuse.
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https://www.hal.inserm.fr/inserm-03648519
Contributor : Odile Malbec Connect in order to contact the contributor
Submitted on : Thursday, April 21, 2022 - 4:12:11 PM
Last modification on : Wednesday, May 4, 2022 - 3:24:04 AM

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Sophie Bargel, Jenny Becam, Lucie Chanu, Thomas Lanot, Marie Martin, et al.. Les gabapentinoïdes : une revue de la littérature. Toxicologie Analytique et Clinique, Elsevier, 2021, 33 (1), pp.44-63. ⟨10.1016/j.toxac.2020.10.019⟩. ⟨inserm-03648519⟩

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